IRAK4 Protein (His tag)
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- 抗原 See all IRAK4 蛋白
- IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This IRAK4 protein is labelled with His tag.
- 原理
- Recombinant Human IRAK4/IRAK-4 Protein (His Tag)(Active)
- 序列
- Met 1-Ser 460
- 产品特性
- A DNA sequence encoding the full length of human IRAK4 (Q9NWZ3-1) (Met 1-Ser 460) was expressed with a polyhistidine tag at the N-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 169 nmol/min/mg using MBP as substrate.
- Top Product
- Discover our top product IRAK4 蛋白
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Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-460) protein (GST tag)
IRAK4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA, KAA
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-460) (Active) protein (GST tag)IRAK4 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-196) protein (GST tag)IRAK4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-130) protein (GST tag)IRAK4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-460) protein (Strep Tag)Crystallography grade IRAK4 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-459) protein (Strep Tag)Crystallography grade IRAK4 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)IRAK4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
- 别名
- IRAK4/IRAK-4 (IRAK4 产品)
- 别名
- zgc:55553 Protein, IRAK4 Protein, ipd1 Protein, irak-4 Protein, ny-ran-64 Protein, ny-ren-64 Protein, ren64 Protein, irak4 Protein, IPD1 Protein, IRAK-4 Protein, NY-REN-64 Protein, REN64 Protein, 8430405M07Rik Protein, 9330209D03Rik Protein, interleukin 1 receptor associated kinase 4 Protein, interleukin-1 receptor-associated kinase 4 Protein, IRAK4 Protein, irak4 Protein, Irak4 Protein
- 背景
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Background: Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4 and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. It also phosphorylates IRAK1. A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. IL-1-mediated IRAK4 kinase activity in T cells is essential for induction of IL-23R expression, Th17 differentiation, and autoimmune disease. Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defence, while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
Synonym: IPD1;IRAK-4;NY-REN-64;REN64
- 分子量
- 53.8 kDa
- 途径
- NF-kappaB Signaling, TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
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