IL12RB1 Protein (His tag)
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- 抗原 See all IL12RB1 蛋白
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL12RB1 protein is labelled with His tag.
- 原理
- Recombinant Human IL12RB1 Protein (His Tag)(Active)
- 序列
- Met 1-Glu 540
- 产品特性
- A DNA sequence encoding the human IL12RB1 isoform 1 (NP_005526.1) extracellular domain (Met 1-Glu 540) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 94 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized human IL12RB1 at 20 μg/ml (100 μl/well) can bind human IL12B with a linear ranger of 2.56-64 ng/ml.
- Top Product
- Discover our top product IL12RB1 蛋白
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Interleukin 12 Receptor beta 1 (IL12RB1) (AA 24-540) protein (His tag)
IL12RB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 24-540) (Active) protein (Fc Tag,AVI tag,Biotin)IL12RB1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 1-381) protein (GST tag)IL12RB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 592-738) protein (His tag)Crystallography grade IL12RB1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 20-565) protein (His tag)Crystallography grade IL12RB1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 24-662) protein (rho-1D4 tag)Crystallography grade IL12RB1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 20-738) protein (rho-1D4 tag)Crystallography grade IL12RB1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 24-540) (Active) protein (His tag)IL12RB1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 12 Receptor beta 1 (IL12RB1) (AA 24-540) (Active) protein (Fc Tag)IL12RB1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- 别名
- IL12RB1 (IL12RB1 产品)
- 别名
- Il12rb Protein, IL12RB1 Protein, IL-12R Protein, CD212 Protein, IL-12R-BETA1 Protein, IL12RB Protein, IL-12R[b] Protein, interleukin 12 receptor subunit beta 1 Protein, interleukin 12 receptor, beta 1 Protein, Il12rb1 Protein, IL12RB1 Protein
- 背景
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Background: Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. It associated with IL12RB2 it forms a functional, high affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Synonym: CD212,IL-12R-BETA1,IL12RB,IMD30, CD212 antigen, IL-12 receptor beta component, IL-12 receptor subunit beta-1, IL12R, IL-12R subunit beta-1, IL12RB, IL-12RB1, IL-12R-BETA1, IL-12R-beta-1, interleukin-12 receptor beta-1 chain, interleukin-12 receptor subunit beta-1
- 分子量
- 58.5 kDa
- NCBI登录号
- NP_005526
- 途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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