CHEK2 Protein (GST tag,His tag)
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- 抗原 See all CHEK2 蛋白
- CHEK2 (Checkpoint Kinase 2 (CHEK2))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- Baculovirus infected Insect Cells
- 标记
- This CHEK2 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Mouse CHK2/CHEK2 Protein (His & GST Tag)(Active)
- 序列
- Mey 1-Leu 546
- 产品特性
- A DNA sequence encoding the mouse CHEK2 (Q9Z265) (Mey 1-Leu 546) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Kinase activity untested
- Top Product
- Discover our top product CHEK2 蛋白
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Checkpoint Kinase 2 (CHEK2) (AA 1-543) protein (GST tag)
CHEK2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Checkpoint Kinase 2 (CHEK2) (AA 1-100) protein (GST tag)CHEK2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Checkpoint Kinase 2 (CHEK2) protein (GST tag)CHEK2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Checkpoint Kinase 2 (CHEK2) (AA 1-543) protein (Strep Tag)Crystallography grade CHEK2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Checkpoint Kinase 2 (CHEK2) (AA 1-546) protein (Strep Tag)Crystallography grade CHEK2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Checkpoint Kinase 2 (CHEK2) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)CHEK2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, PI, STD Active
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.0
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- CHEK2 (Checkpoint Kinase 2 (CHEK2))
- 别名
- CHK2/CHEK2 (CHEK2 产品)
- 别名
- CDS1 Protein, CHK2 Protein, HuCds1 Protein, LFS2 Protein, PP1425 Protein, RAD53 Protein, hCds1 Protein, fa66f08 Protein, wu:fa66f08 Protein, zgc:55865 Protein, Cds1 Protein, HUCDS1 Protein, Rad53 Protein, Chk2 Protein, cds1 Protein, chek2 Protein, chk2 Protein, hucds1 Protein, lfs2 Protein, pp1425 Protein, rad53 Protein, checkpoint kinase 2 Protein, serine/threonine-protein kinase chk2 Protein, checkpoint kinase 2 L homeolog Protein, CHEK2 Protein, chek2 Protein, Chek2 Protein, MCYG_07308 Protein, chek2.L Protein
- 背景
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Background: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded CHEK2 protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in CHEK2s gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Cds1;CHK2;HUCDS1;Rad53
- 分子量
- 89 kDa
- UniProt
- Q9Z265
- 途径
- p53 Pathway, Apoptosis, Cell Division Cycle
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