CD70 Protein (Fc Tag)
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- 抗原 See all CD70 蛋白
- CD70 (CD70 Molecule (CD70))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This CD70 protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse TNFSF7/CD70 Protein (Fc Tag)(Active)
- 序列
- Gln47-Pro195
- 产品特性
- A DNA sequence encoding the mouse Cd70 (NP_035747.1) (Gln47-Pro195) was expressed with the Fc region of mouse IgG1 at the N-terminus.
- 纯度
- > (12.5+86.3) % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- 1.Measured by its binding ability in a functional ELISA.2.Immobilized mouse CD27-His at 10μg/mL (100μL/well) can bind mouse CD70 , the EC50 of mouse CD70 is 10-50 ng/mL.
- Top Product
- Discover our top product CD70 蛋白
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CD70 Molecule (CD70) (AA 39-193) protein (Fc Tag)
CD70 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD70 Molecule (CD70) (AA 45-195) protein (Fc Tag)CD70 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD70 Molecule (CD70) (Trimer) protein (His tag)CD70 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
CD70 Molecule (CD70) (Trimer) protein (His tag,Biotin)CD70 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD70 Molecule (CD70) protein (mFc-His Tag)CD70 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
CD70 Molecule (CD70) (AA 39-194) protein (His tag)CD70 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,
CD70 Molecule (CD70) (AA 52-193) protein (His-DYKDDDDK-Strep II Tag)CD70 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
CD70 Molecule (CD70) (AA 52-193) (Active) protein (Fc Tag)CD70 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD70 Molecule (CD70) (AA 52-193) (Active) protein (DYKDDDDK Tag,His tag)CD70 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD70 Molecule (CD70) (AA 52-193) (Active) protein (His tag,AVI tag,DYKDDDDK Tag,Biotin)CD70 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CD70 (CD70 Molecule (CD70))
- 别名
- TNFSF7/CD70 (CD70 产品)
- 别名
- CD27LG Protein, Cd27l Protein, Tnfsf7 Protein, CD27L Protein, TNFSF7 Protein, CD70 antigen Protein, CD70 molecule Protein, Cd70 molecule Protein, Cd70 Protein, CD70 Protein
- 背景
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Background: CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Immune CheckpointImmune Checkpoint ProteinsImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Cd27l;CD27LG;Tnfsf7
- 分子量
- 43.1 kDa
- NCBI登录号
- NP_035747
- 途径
- Cancer Immune Checkpoints
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