AXL Protein (His tag,Fc Tag)
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- 抗原 See all AXL 蛋白
- AXL (AXL Receptor tyrosine Kinase (AXL))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This AXL protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Mouse Axl Kinase Protein (His & Fc Tag)
- 序列
- Met 1-Pro 443
- 产品特性
- A DNA sequence encoding the extracellular domain (Met 1-Pro 443) of mouse AXL (NP_033491.2) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product AXL 蛋白
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AXL Receptor tyrosine Kinase (AXL) (AA 33-442) protein (His tag)
AXL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
AXL Receptor tyrosine Kinase (AXL) (AA 33-449) protein (His tag)AXL 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
AXL Receptor tyrosine Kinase (AXL) protein (His-Avi Tag)AXL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by SEC-HPLC
AXL Receptor tyrosine Kinase (AXL) (AA 26-449) protein (Fc Tag)AXL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
AXL Receptor tyrosine Kinase (AXL) protein (His-Avi Tag,Biotin)AXL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
AXL Receptor tyrosine Kinase (AXL) (AA 26-449) protein (Fc Tag,Biotin)AXL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
AXL Receptor tyrosine Kinase (AXL) (AA 473-894) protein (His tag)Crystallography grade AXL 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
AXL Receptor tyrosine Kinase (AXL) (AA 20-445) protein (His tag)AXL 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
AXL Receptor tyrosine Kinase (AXL) (AA 464-885) (Active) protein (GST tag)AXL 宿主: 人 宿主: Insect Cells Recombinant SDS, Func Active
AXL Receptor tyrosine Kinase (AXL) (AA 464-885) (Active) protein (His-GST)AXL 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- AXL (AXL Receptor tyrosine Kinase (AXL))
- 别名
- Axl Kinase (AXL 产品)
- 别名
- JTK11 Protein, UFO Protein, AI323647 Protein, Ark Protein, Tyro7 Protein, Ufo Protein, AXL receptor tyrosine kinase Protein, Axl receptor tyrosine kinase Protein, AXL Protein, Axl Protein
- 背景
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Background: Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.
Synonym: AI323647,Ark,Tyro7,Ufo
- 分子量
- 74.5 kDa
- NCBI登录号
- NP_033491
- 途径
- RTK signaling, Cellular Response to Molecule of Bacterial Origin
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