SARS-CoV-2 Spike Protein (N501Y, RBD) (Fc Tag)
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- 抗原 See all SARS-CoV-2 Spike 蛋白
- SARS-CoV-2 Spike
- 蛋白类型
- Recombinant
- 产品特性
- N501Y, RBD
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宿主
- SARS Coronavirus-2 (SARS-CoV-2)
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资源
- HEK-293 Cells
- 标记
- This SARS-CoV-2 Spike protein is labelled with Fc Tag.
- 原理
- SARS-CoV-2 Spike Protein RBD (Mammalian, N501Y, C-Fc)
- 产品特性
- Recombinant 2019-nCoV S-RBD is produced by Mammalian expression system and the target gene encoding Arg319-Ser541(N501Y) is expressed with a Fc tag at the C-terminus.
- Top Product
- Discover our top product SARS-CoV-2 Spike 蛋白
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
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- 抗原
- SARS-CoV-2 Spike
- 别名
- SARS-CoV-2 S Protein (SARS-CoV-2 Spike 产品)
- 别名
- E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein
- 物质类
- Viral Protein
- 背景
- The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell during the initial stages of the infection process. The SARS-CoV-2 Spike Protein mediates the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. SARS-CoV-2 infects the human respiratory epithelial cells through interaction with the human ACE2 receptor. The Spike Protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The Spike Protein plays key a part in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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