Bcl-2 Protein (AA 1-211) (His tag)
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- 抗原 See all Bcl-2 (BCL2) 蛋白
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-211
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This Bcl-2 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 产品特性
- Bcl-2, 1-211 aa, Human, His-tagged, Recombinant, E.coli
- 纯度
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product BCL2 蛋白
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/ml (determined by Bradford assay)
- 缓冲液
- Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 20% glycerol 2 mM DTT
- 储存条件
- 4 °C
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- 抗原
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- 别名
- Bcl-2 (BCL2 产品)
- 别名
- Bcl-2 Protein, PPP1R50 Protein, bcl-2 Protein, AW986256 Protein, C430015F12Rik Protein, D630044D05Rik Protein, D830018M01Rik Protein, BCL-2 Protein, Bcl2 Protein, BCL2, apoptosis regulator Protein, B cell leukemia/lymphoma 2 Protein, B-cell CLL/lymphoma 2a Protein, B-cell CLL/lymphoma 2 protein Protein, BCL2 Protein, Bcl2 Protein, bcl2a Protein, BCL-2 Protein
- 背景
- Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apotosis. Bcl-2 exerts its anti-apoptotic function through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). The Bcl-2 gene has been related with a number of cancers, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity. Recombinant Bcl-2 protein was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Synonyms: B-cell lymphoma protein 2 alpha , B-cell lymphoma protein 2 alpha Apoptosis regulator Bcl 2, Apoptosis regulator Bcl2, AW986256, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, Bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, B-cell, 2, Oncogene B-cell leukemia 2. NCBI no.: NP_000624
- 分子量
- 25.4 kDa (231 aa), confirmed by MALDI-TOF.
- 途径
- MAPK Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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