Prolactin Receptor Protein (PRLR) (AA 25-234) (His tag)
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- 抗原 See all Prolactin Receptor (PRLR) 蛋白
- Prolactin Receptor (PRLR)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 25-234
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Prolactin Receptor protein is labelled with His tag.
- 序列
- AA 25-234
- 产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product PRLR 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM Tris, 150 mM NaCl, pH 7.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- Prolactin Receptor (PRLR)
- 别名
- Prolactin R (PRLR 产品)
- 背景
- As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
- 分子量
- 26.3 kDa
- NCBI登录号
- NP_000940
- 途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
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