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KLRK1 Protein (AA 73-216) (hIgG-His-tag)
KLRK1
宿主: 人
宿主: Baculovirus infected Insect Cells
Recombinant
> 95 % by SDS - PAGE
SDS
产品细节
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抗原
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KLRK1
(Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
蛋白类型
Recombinant
产品特性
AA 73-216
宿主
All origins for KLRK1 蛋白
人
资源
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Baculovirus infected Insect Cells
标记
This KLRK1 protein is labelled with hIgG-His-tag.
应用范围
SDS-PAGE (SDS)
序列
ADPIWSAVFL NSLFNQEVQI PLTESYCGPC PKNWICYKNN CYQFFDESKN WYESQASCMS QNASLLKVYS KEDQDLLKLV KSYHWMGLVH IPTNGSWQWE DGSILSPNLL TIIEMQKGDC ALYASSFKGY IENCSTPNTY ICMQRTVVEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH
纯度
> 95 % by SDS - PAGE
内毒素水平
< 1.0 EU per 1ug of protein (determined by LAL method)
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使用细节
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应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
0.5 mg/mL
缓冲液
Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 10 % glycerol.
储存条件
4 °C,-20 °C,-80 °C
储存方法
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
目标详细情况
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抗原
KLRK1
(Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
别名
KLRK1 (KLRK1 产品 )
别名
KLRK1 Protein, NKG2D Protein, CD314 Protein, D12S2489E Protein, KLR Protein, NKG2-D Protein, D6H12S2489E Protein, Nkg2d Protein, Nkrp2 Protein, killer cell lectin like receptor K1 Protein, killer cell lectin-like receptor subfamily K, member 1 Protein, NKG2D protein Protein, KLRK1 Protein, Klrk1 Protein, NKG2D Protein
背景
KLRK1, also known as NKG2D ligand 4 isoform 1, is a type ll transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. It can send co-stimulatory signals to activate CD8 T cells. Also, it plays an important role in viral control. Cellular stress can induce ligands for KLRK1 which results in the cell susceptible to NK cell-mediated lysis. Recombinant human KLRK1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
分子量
43.9kDa (386aa) 40-57kDa (SDS-PAGE under reducing conditions.)
NCBI登录号
NP_031386
UniProt
P26718
途径
Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process
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KLRK1 蛋白
KLRK1 Protein (AA 73-216) (hIgG-His-tag) (ABIN7281286)