KLRK1 Protein (AA 73-216) (mFc Tag)
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- 抗原 See all KLRK1 蛋白
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 73-216
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This KLRK1 protein is labelled with mFc Tag.
- 产品特性
- Human NKG2D / CD314 Protein, Mouse IgG2a Fc Tag
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 0.1 EU per μg by the LAL method.
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- Discover our top product KLRK1 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
- 储存条件
- -20 °C
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- 抗原
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
- 别名
- NKG2D (KLRK1 产品)
- 背景
- NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.
- 分子量
- 43.5 kDa
- 途径
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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