MUSK Protein (AA 24-495, Cytoplasmic Domain, Cytosolic) (His tag)
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- 抗原 See all MUSK 蛋白
- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
- 蛋白类型
- Recombinant
- 产品特性
- AA 24-495, Cytosolic, Cytoplasmic Domain
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宿主
- 人
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资源
- 酵母菌
- 标记
- This MUSK protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- LPKAPVITTP LETVDALVEE VATFMCAVES YPQPEISWTR NKILIKLFDT RYSIRENGQL LTILSVEDSD DGIYCCTANN GVGGAVESCG ALQVKMKPKI TRPPINVKII EGLKAVLPCT TMGNPKPSVS WIKGDSPLRE NSRIAVLESG SLRIHNVQKE DAGQYRCVAK NSLGTAYSKV VKLEVEEESE PEQDTKVFAR ILRAPESHNV TFGSFVTLHC TATGIPVPTI TWIENGNAVS SGSIQESVKD RVIDSRLQLF ITKPGLYTCI ATNKHGEKFS TAKAAATISI AEWREYCLAV KELFCAKEWL VMEEKTHRGL YRSEMHLLSV PECSKLPSMH WDPTACARLP HLAFPPMTSS KPSVDIPNLP SSSSSSFSVS PTYSMTVIIS IMSSFAIFVL LTITTLYCCR RRKQWKNKKR ESAAVTLTTL PSELLLDRLH PNPMYQRMPL LLNPKLLSLE YPRNNIEYVR DI
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product MUSK 蛋白
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Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 24-495) protein (His tag)
Crystallography grade MUSK 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 756-869) protein (His-IF2DI Tag)MUSK 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) protein (GST tag)MUSK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 22-468) protein (His tag)MUSK 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 433-783) protein (GST tag,His tag)MUSK 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
- 别名
- MUSK (MUSK 产品)
- 别名
- unp Protein, fj98e12 Protein, zgc:63467 Protein, wu:fj98e12 Protein, si:dz46m7.2 Protein, si:dz57f23.3 Protein, si:busm1-57f23.3 Protein, musk-A Protein, MuSK Protein, MUSK Protein, Mdk4 Protein, Mlk Protein, Nsk1 Protein, Nsk2 Protein, Nsk3 Protein, muscle Protein, muscle associated receptor tyrosine kinase Protein, muscle, skeletal, receptor tyrosine kinase Protein, muscle associated receptor tyrosine kinase S homeolog Protein, MUSK Protein, musk Protein, musk.S Protein, Musk Protein
- 背景
- Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle . Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic mbrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to mbranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous syst by mediating cholinergic responses, synaptic plasticity and mory formation .1 Publication
- 分子量
- 54.5 kDa
- UniProt
- O15146
- 途径
- RTK signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
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