MUSK Protein (AA 433-783) (GST tag,His tag)
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- 抗原 See all MUSK 蛋白
- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
- 蛋白类型
- Recombinant
- 产品特性
- AA 433-783
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This MUSK protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human MUSK Kinase Protein (aa 433-783, His & GST Tag)
- 序列
- Arg 433-Val 783
- 产品特性
- A DNA sequence encoding the C-terminal segment of human MUSK isoform 2 (O15146-2) (Arg 433-Val 783) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product MUSK 蛋白
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Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 24-495) protein (His tag)
Crystallography grade MUSK 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 527-869) (Active) protein (GST tag)MUSK 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 529-869) (Active) protein (His-GST)MUSK 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 756-869) protein (His-IF2DI Tag)MUSK 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) protein (GST tag)MUSK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 22-468) protein (His tag)MUSK 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 517-869) protein (His tag)Crystallography grade MUSK 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 516-868) protein (His tag)Crystallography grade MUSK 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 22-494) protein (His tag)Crystallography grade MUSK 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 24-869) protein (rho-1D4 tag)Crystallography grade MUSK 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 mM GSH.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
- 别名
- MUSK Kinase (MUSK 产品)
- 别名
- unp Protein, fj98e12 Protein, zgc:63467 Protein, wu:fj98e12 Protein, si:dz46m7.2 Protein, si:dz57f23.3 Protein, si:busm1-57f23.3 Protein, musk-A Protein, MuSK Protein, MUSK Protein, Mdk4 Protein, Mlk Protein, Nsk1 Protein, Nsk2 Protein, Nsk3 Protein, muscle Protein, muscle associated receptor tyrosine kinase Protein, muscle, skeletal, receptor tyrosine kinase Protein, muscle associated receptor tyrosine kinase S homeolog Protein, MUSK Protein, musk Protein, musk.S Protein, Musk Protein
- 背景
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Background: Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. MUSK expression is increased in muscle cells stimulated with Wnt or at conditions when the Wnt signaling was activated. MUSK is a muscle-specific receptor tyrosine kinase that is activated by agrin. It has a critical role in neuromuscular synapse formation. MUSK is a receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization. Defects in MUSK encoding gene is a cause of autosomal recessive congenital myasthenic syndrome (CMS). Congenital myasthenic syndromes are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction. Mutations in this receptor encoding gene also have been associated with congenital myasthenic syndrome.
Synonym: CMS9,FADS
- 分子量
- 68 kDa
- 途径
- RTK signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
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