AKT1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- 抗原 See all AKT1 蛋白
- AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
- 蛋白类型
- Recombinant
- 产品特性
- Transcript Variant 1
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This AKT1 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human AKT1 / PKB (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product AKT1 蛋白
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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Inhibition of pressure-activated cancer cell adhesion by FAK-derived peptides." in: Oncotarget, Vol. 8, Issue 58, pp. 98051-98067, (2017) (PubMed).
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Inhibition of pressure-activated cancer cell adhesion by FAK-derived peptides." in: Oncotarget, Vol. 8, Issue 58, pp. 98051-98067, (2017) (PubMed).
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- 抗原
- AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
- 别名
- Akt1,pkb (AKT1 产品)
- 别名
- AKT Protein, CWS6 Protein, PKB Protein, PKB-ALPHA Protein, PRKBA Protein, RAC Protein, RAC-ALPHA Protein, Akt Protein, Rac Protein, PKB/Akt Protein, PKBalpha Protein, AKT/PKB Protein, AKT1 Protein, Akt/PKB Protein, Akt1 Protein, CG4006 Protein, D-Akt Protein, DAKT1 Protein, DAKT1/PKB Protein, DAkt Protein, DAkt1 Protein, DPKB Protein, DRAC-PK Protein, DRAC-PK66 Protein, DRAC-PK85 Protein, Dakt Protein, Dakt1 Protein, Dmel\\CG4006 Protein, Dpkb Protein, PKB/AKT Protein, PKB/dAKT Protein, RacPK Protein, akt Protein, akt1 Protein, dAKT Protein, dAKT/dPKB Protein, dAKT1 Protein, dAkt Protein, dAkt/PKB Protein, dAkt1 Protein, dPKB Protein, dakt Protein, dakt1 Protein, l(3)04226 Protein, l(3)89Bq Protein, p-Akt Protein, pAkt Protein, ACT-5 Protein, akt-1 Protein, pkb Protein, v-akt Protein, v-akt1 Protein, xAct Protein, ATAKT1 Protein, F18A8.2 Protein, F18A8_2 Protein, K+ transporter 1 Protein, POTASSIUM TRANSPORTER Protein, AKT serine/threonine kinase 1 Protein, thymoma viral proto-oncogene 1 Protein, CG4006 gene product from transcript CG4006-RE Protein, actin beta Protein, v-akt murine thymoma viral oncogene homolog 1 S homeolog Protein, v-akt murine thymoma viral oncogene homolog 1 Protein, K+ transporter 1 Protein, Serine/threonine-protein kinase akt-1 Protein, AKT1 Protein, Akt1 Protein, ACTB Protein, akt1.S Protein, akt1 Protein, KT1 Protein, akt-1 Protein
- 背景
- The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
- 分子量
- 55.5 kDa
- NCBI登录号
- NP_005154
- 途径
- PI3K-Akt Signaling, RTK signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Water Deprivation, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGFR1 Specific Signals, VEGF Signaling, Warburg Effect
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