IL1RN Protein (AA 26-177)
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- 抗原 See all IL1RN 蛋白
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 26-177
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- Flow Cytometry (FACS)
- 纯度
- >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
- 内毒素水平
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Less than 0.1 ng per μg of protein.
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- Discover our top product IL1RN 蛋白
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Interleukin 1 Receptor Antagonist (IL1RN) (AA 1-159) protein (GST tag)
IL1RN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 1 Receptor Antagonist (IL1RN) (AA 25-178) protein (His tag)IL1RN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 1 Receptor Antagonist (IL1RN) protein (Fc Tag)IL1RN 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 1 Receptor Antagonist (IL1RN) proteinIL1RN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Biological activity: ED50 is 20 - 40 ng/ml in the presence of 50 pg/ml of IL-1α, corresponding to a specific activity of 2.5 - 5.0 x 105 units/mg as determined by its ability to inhibit the IL-1α stimulation of murine D10S cell.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
- 缓冲液
- Lyophilized, carrier-free.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- 抗原
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- 别名
- IL-1RA (IL1RN 产品)
- 别名
- DIRA Protein, ICIL-1RA Protein, IL-1RN Protein, IL-1ra Protein, IL-1ra3 Protein, IL1F3 Protein, IL1RA Protein, IRAP Protein, MVCD4 Protein, IRAP1 Protein, IL1RN Protein, IL-1RA Protein, F630041P17Rik Protein, interleukin 1 receptor antagonist Protein, interleukin 1 receptor antagonist-like Protein, IL1RN Protein, Il1rn Protein, IL1RNL Protein
- 背景
- Interleukin-1 receptor antagonist (IL-1RA or IL-RN) is a member of IL-1 family cytokine and it is a naturally occurring inflammatory inhibitor protein. It competes with IL-1α and IL-1β for binding to type I and type II receptors. It can modulate a variety of interleukin 1 related immune and inflammatory responses. IL-1RA has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo model. Recombinant IL-1RA (anakinra) has been used as to treat rheumatoid arthritis. A polymorphism of IL-1RN gene is reported to be associated with increased risk of osteoporotic fractures, gastric cancer, bladder cancer, and other cancer types.
- 分子量
- The 153 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 17.2 kDa. The predicted N-terminal amino acid is Met.
- 途径
- NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
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