MICA
(MHC Class I Polypeptide-Related Sequence A (MICA))
蛋白类型
Recombinant
产品特性
AA 24-308
宿主
人
资源
HEK-293 Cells
标记
This MICA protein is labelled with His tag.
序列
AA 24-308
产品特性
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
MICA
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
限制
仅限研究用
状态
Lyophilized
缓冲液
PBS, pH 7.4
注意事项
Please avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Srpan, Ambrose, Karampatzakis, Saeed, Cartwright, Guldevall, De Matos, Önfelt, Davis: "Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells." in: The Journal of cell biology, Vol. 217, Issue 9, pp. 3267-3283, (2018) (PubMed).
抗原
MICA
(MHC Class I Polypeptide-Related Sequence A (MICA))
MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein
背景
MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.