Human Leukocyte Antigen (HLA) in Adaptive Immune Response

The Major Histocompatibility Complex (MHC) comprises a number of genes that occur in many species. The encoded proteins help the immune system to tell the body's own proteins apart from those of pathogens such as viruses, bacteria, and protozoans. In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. A third cluster of HLAs (class III HLAs), situated between class I and class II HLAs, encodes components of the complement system and is not involved in the adaptive immune response.

Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. Many observations point to a major role for classical HLA loci in determining susceptibility to viral infections1. A recent study shows that individuals with the allele HLA-B*46:01 have the fewest predicted binding peptides for SARS-CoV-2, suggesting they may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS. A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. 2 These observations point towards a potential influence of different HLA composition - the haplotype - in the present SARS-CoV-2 pandemic. Association of various HLA haplotypes with SARS-CoV-2 infection and the course of COVID-19 could improve assessment of viral severity in the population. Thus, it could allow strategizing prevention, treatment, vaccination, and optimizing clinical approaches3.

Additional SARS-CoV-2 Resources:


  1. Blackwell, Jamieson, Burgner (2009) "HLA and infectious diseases" Clin Microbiol Rev.; 22(2):370-85
  2. Nguyen et al. (2020) "Human leukocyte antigen susceptibility map for SARS-CoV-2"; medRxiv
  3. Shi et al. (2020) "COVID-19 infection: the perspectives on immune responses" Cell Death Differ. (ePrint)

HLA Class I Genes

HLA-A (Major Histocompatibility Complex, Class I, A): HLA-A 抗体 HLA-A ELISA试剂盒 HLA-A 蛋白
HLA-B (Major Histocompatibility Complex, Class I, B): HLA-B 抗体 HLA-B ELISA试剂盒 HLA-B 蛋白
HLA-C - Major Histocompatibility Complex Class I C: HLA-C 抗体 HLA-C ELISA试剂盒 HLA-C 蛋白
HLA-E - HLA Class I Histocompatibility Antigen, alpha Chain E: HLA-E 抗体 HLA-E ELISA试剂盒 HLA-E 蛋白
HLAF - HLA Class I alpha F: HLAF 抗体 HLAF ELISA试剂盒 HLAF 蛋白
HLAG - HLA Class I Histocompatibility Antigen, alpha Chain G: HLAG 抗体 HLAG ELISA试剂盒 HLAG 蛋白

HLA Class II Genes

HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1): HLA-DRB1 抗体 HLA-DRB1 ELISA试剂盒 HLA-DRB1 蛋白
HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3): HLA-DRB3 抗体   HLA-DRB3 蛋白
HLA-DRB4 - Major Histocompatibility Complex, Class II, DR beta 4: HLA-DRB4 抗体   HLA-DRB4 蛋白
HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5): HLA-DRB5 抗体 HLA-DRB5 ELISA试剂盒 HLA-DRB5 蛋白
HLA-DQA1 - Major Histocompatibility Complex, Class II, DQ alpha 1: HLA-DQA1 抗体   HLA-DQA1 蛋白
HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1): HLA-DQB1 抗体 HLA-DQB1 ELISA试剂盒 HLA-DQB1 蛋白
HLA-DPA1 - Major Histocompatibility Complex, Class II, DP alpha 1: HLA-DPA1 抗体   HLA-DPA1 蛋白
HLA-DPB1 (Major Histocompatibility Complex, Class II, DP beta 1): HLA-DPB1 抗体   HLA-DPB1 蛋白
HLA-DMA - Major Histocompatibility Complex, Class II, DM alpha: HLA-DMA 抗体 HLA-DMA ELISA试剂盒 HLA-DMA 蛋白
HLA-DMB (Major Histocompatibility Complex, Class II, DM beta): HLA-DMB 抗体   HLA-DMB 蛋白
HLA-DOA (HLA Class II DO alpha): HLA-DOA 抗体   HLA-DOA 蛋白
HLA-DOB (Major Histocompatibility Complex, Class II, DO beta): HLA-DOB 抗体   HLA-DOB 蛋白

HLA Class I Pseudogenes

HLA-H (Major Histocompatibility Complex, Class I, H (Pseudogene)): HLA-H 抗体    

Other Genes within the MHC

MICA (MHC Class I Polypeptide-Related Sequence A): MICA 抗体 MICA ELISA试剂盒 MICA 蛋白
MICB (MHC Class I Polypeptide-Related Sequence B): MICB 抗体 MICB ELISA试剂盒 MICB 蛋白
TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP)): TAP1 抗体 TAP1 ELISA试剂盒 TAP1 蛋白
TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP)): TAP2 抗体 TAP2 ELISA试剂盒 TAP2 蛋白