Complement System

补体系统是先天免疫系统的一部分，对提高机体免疫力、炎症、组织再生和其他生理进程起着非常重要的作用。补体激活不仅会引起病原体调理并被吞噬细胞清除，而且还会导致吞噬细胞和巨噬细胞的趋化现象。此外，补体系统还会形成终端抗体复合物(MAC)，一个膜通道引起相应的病原体发生渗透性溶解。当补体无法适应时，可补给获得性免疫系统并且包含于B和T细胞反应调节。

补体激活会根据病原体的自然特性展开三种不同长度的补体激活途径：常规途径、凝集素途径和旁路途径。以上三种途径均会汇聚到常规终端途径并形成MAC。此外，C3a和C5a灭活因子会诱发生理学上的多血症，导致发生化学反应范围内的脱噬作用。补体系统包含的30多种蛋白质为可溶于血液中的可溶性蛋白，抑或是与蛋白相关的膜。多数现有的不活跃酵素原随后会相继被分裂并激活。所有三种途径中的中体均为C3（血液中含量最多的补给蛋白）。补体激活涵盖C3a、C3b和C5a的激活形成以及最终的MAC。

补体激活除了上述三种稳定途径之外，因子（例如胰舒血管素、胞浆素、凝血酶）以及XIIa还可单独激活补体系统，这样不需要C3蛋白。

Download pathway image as PDF

Classical Pathway

C1QA (Complement Component 1, Q Subcomponent, A Chain):

Western blot analysis of C1QA antibody (C-term) (ABIN391492) in Jurkat cell line lysates (35 µg/lane). C1QA (arrow) was detected using the purified polyclonal antibody.

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first...

C1QA 抗体

C1QA ELISA试剂盒

C1QA 蛋白

C1QB (Complement Component 1, Q Subcomponent, B Chain):

Western blot analysis of C1QB Antibody (N-term) (ABIN652840) in Jurkat cell line lysates (35 µg/lane). C1QB (arrow) was detected using the purified polyclonal antibody.

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first...

C1QB 抗体

C1QB ELISA试剂盒

C1QB 蛋白

C1QC (Complement Component 1, Q Subcomponent, C Chain):

C1QC Antibody (Center) (ABIN655873) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first...

C1QC 抗体

C1QC ELISA试剂盒

C1QC 蛋白

C1R (Complement Component 1, R Subcomponent):

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

WB Image Sample (30 ug of whole cell lysate) A: Molt-4 , 7.5% SDS PAGE antibody diluted at 1:1000

C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.

C1R 抗体

C1R ELISA试剂盒

C1R 蛋白

此分类里的别的抗原：

C1S (Complement Component 1, S Subcomponent):	C1S 抗体	C1S ELISA试剂盒	C1S 蛋白
C4A (Complement Fragment 4a):	C4A 抗体	C4A ELISA试剂盒	C4A 蛋白
C4 - Complement 4:	C4 抗体	C4 ELISA试剂盒	C4 蛋白
C4B (Complement Component 4B):	C4B 抗体	C4B ELISA试剂盒	C4B 蛋白

Lectin Pathway

MASP1 (Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor)):

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti- MASP Polyclonal Antibody, Unconjugated (ABIN733508) at 1:200, followed by conjugation to the secondary antibody and DAB staining.

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This... 更多...

此分类里的别的抗原：

MBL2 (Mannose-Binding Lectin (Protein C) 2, Soluble):	MBL2 抗体	MBL2 ELISA试剂盒	MBL2 蛋白
MASP2 (Mannan-Binding Lectin serine Peptidase 2):	MASP2 抗体	MASP2 ELISA试剂盒	MASP2 蛋白
FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1):	FCN1 抗体	FCN1 ELISA试剂盒	FCN1 蛋白
FCN2 (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin)):	FCN2 抗体	FCN2 ELISA试剂盒	FCN2 蛋白
FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen)):	FCN3 抗体	FCN3 ELISA试剂盒	FCN3 蛋白

Alternative Pathway

CFB - Complement Factor B

Immunohistochemistry of paraffin-embedded mouse kidney using CFB antibody at dilution of 1:200 (x400 lens)

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a...

CFB 抗体

CFB ELISA试剂盒

CFB 蛋白

CFD - Adipsin

CFD Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CFD antibody detected the CFD protein (arrow).

Western blot analysis of the recombinant protein.

Detection limit for recombinant GST tagged CFD is 0.03 ng/ml as a capture antibody.

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement...

CFD 抗体

CFD ELISA试剂盒

CFD 蛋白

此分类里的别的抗原：

C3 (Complement Component 3):	C3 抗体	C3 ELISA试剂盒	C3 蛋白
C3B - Complement Component C3b:	C3B 抗体
CFH - Complement Factor H:	CFH 抗体	CFH ELISA试剂盒	CFH 蛋白

Terminal Pathway

C5 - Complement Component 5

Western blot analysis of C5 Antibody (N-term) (ABIN652518) in HL-60 cell line lysates (35 µg/lane). C5 (arrow) was detected using the purified polyclonal antibody.(2 µg/mL)

Formalin-fixed and paraffin embedded: Human laryngeal carcinoma labeled with Anti-C5a Polyclonal Antibody (ABIN727875), Unconjugated at 1:200, followed by conjugation to the secondary antibody was Goat Anti-Rabbit IgG, PE conjugated at 1:200 for 40 minutes at 37°C

Immunohistochemical analysis of Complement C5 staining in human stomach formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha... 更多...

抗体

208 产品

ELISA试剂盒

78 产品

蛋白

23 产品

此分类里的别的抗原：

C5a - C5A:	C5a 抗体	C5a ELISA试剂盒	C5a 蛋白
C7 (Complement Component C7):	C7 抗体	C7 ELISA试剂盒	C7 蛋白
C8A (Complement Component 8, alpha Polypeptide):	C8A 抗体	C8A ELISA试剂盒	C8A 蛋白
C8B (Complement Component 8, beta Polypeptide):	C8B 抗体	C8B ELISA试剂盒	C8B 蛋白
C8G (Complement Component 8, gamma Polypeptide):	C8G 抗体	C8G ELISA试剂盒	C8G 蛋白
C9 (Complement Component C9):	C9 抗体	C9 ELISA试剂盒	C9 蛋白

Regulators

CD55 (Complement Decay-Accelerating Factor):

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-CD55/DAF Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Immunochemical staining of human CD55 in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).

This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating...

CD55 抗体

CD55 ELISA试剂盒

CD55 蛋白

CD59 (CD59):

Western Blot analysis of CD59 expression in transfected 293T cell line by CD59 MaxPab polyclonal antibody. Lane 1: CD59 transfected lysate(14.20 KDa). Lane 2: Non-transfected lysate.

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction....

CD59 抗体

CD59 ELISA试剂盒

CD59 蛋白

此分类里的别的抗原：

SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1):	SERPING1 抗体	SERPING1 ELISA试剂盒	SERPING1 蛋白
CFI - Complement Factor I:	CFI 抗体	CFI ELISA试剂盒	CFI 蛋白
CR1 (Complement Component Receptor 1 (CD35)):	CR1 抗体	CR1 ELISA试剂盒
CFP (Complement Factor P):	CFP 抗体	CFP ELISA试剂盒	CFP 蛋白
C4BPA (Complement Component 4 Binding Protein, alpha):	C4BPA 抗体	C4BPA ELISA试剂盒	C4BPA 蛋白
C4BPB (Complement Component 4 Binding Protein, beta):	C4BPB 抗体	C4BPB ELISA试剂盒	C4BPB 蛋白

Extrinsic Pathway

F2 - Prothrombin

Western blot analysis of (1) Rat Serum and (2) Rat Liver Tissue.

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]. 更多...

抗体

276 产品

ELISA试剂盒

148 产品

蛋白

48 产品

此分类里的别的抗原：

PLG (Plasminogen):	PLG 抗体	PLG ELISA试剂盒	PLG 蛋白
KLK1 - Kallikrein 1:	KLK1 抗体	KLK1 ELISA试剂盒	KLK1 蛋白
KLK2 - Kallikrein 2:	KLK2 抗体	KLK2 ELISA试剂盒	KLK2 蛋白
PSA - Prostate Specific Antigen:	PSA 抗体	PSA ELISA试剂盒	PSA 蛋白
KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1):	KLKB1 抗体	KLKB1 ELISA试剂盒	KLKB1 蛋白
KLK4 - Kallikrein 4:	KLK4 抗体	KLK4 ELISA试剂盒	KLK4 蛋白
KLK5 - Kallikrein 5:	KLK5 抗体	KLK5 ELISA试剂盒	KLK5 蛋白
KLK6 - Kallikrein 6:	KLK6 抗体	KLK6 ELISA试剂盒	KLK6 蛋白
KLK7 - Kallikrein 7:	KLK7 抗体	KLK7 ELISA试剂盒	KLK7 蛋白
KLK8 - Kallikrein 8:	KLK8 抗体	KLK8 ELISA试剂盒	KLK8 蛋白
KLK9 - Kallikrein 9:	KLK9 抗体	KLK9 ELISA试剂盒	KLK9 蛋白
KLK10 - Kallikrein 10:	KLK10 抗体	KLK10 ELISA试剂盒	KLK10 蛋白
PRSS57 (Protease, Serine, 57):	PRSS57 抗体		PRSS57 蛋白
KLK11 - Kallikrein 11:	KLK11 抗体	KLK11 ELISA试剂盒	KLK11 蛋白
KLK12 - Kallikrein 12:	KLK12 抗体	KLK12 ELISA试剂盒	KLK12 蛋白
KLK13 - Kallikrein 13:	KLK13 抗体	KLK13 ELISA试剂盒	KLK13 蛋白
KLK14 - Kallikrein 14:	KLK14 抗体	KLK14 ELISA试剂盒	KLK14 蛋白
KLK15 - Kallikrein 15:	KLK15 抗体	KLK15 ELISA试剂盒	KLK15 蛋白
F12 - Coagulation Factor XII (Hageman Factor):	F12 抗体	F12 ELISA试剂盒	F12 蛋白

电话:	+1 877 302 8632
传真:	+1 888 205 9894 (Toll-free)
电子邮件:	orders@antibodies-online.cn