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F12 蛋白

(Coagulation Factor XII (F12))
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].
F12 Protein (AA 191-300) (GST tag) F12 Protein (AA 191-300) (GST tag) F12 Protein (AA 191-300) (GST tag) (ABIN1353303)

F12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

F12 Protein (AA 1-300) (GST tag) F12 Protein (AA 1-300) (GST tag) F12 Protein (AA 1-300) (GST tag) (ABIN1353299)

F12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

F12 Protein (AA 373-615) (His tag) F12 Protein (AA 373-615) (His tag) F12 Protein (AA 373-615) (His tag) (ABIN3079848)

Crystallography grade F12 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

F12 蛋白 by Grade

Find F12 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

F12 蛋白 by Origin

Find F12 蛋白 for a variety of species such as anti-Human F12, anti-Mouse F12, anti-Cow F12. The species listed below are among those available. Click on a link to go to the corresponding products.

F12 蛋白 by Source

Here you will find F12 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

F12 蛋白 by 蛋白类型

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F12 蛋白 by 应用范围

Find F12 蛋白 validated for a specific application such as ELISA, WB, SDS, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular F12 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353303
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353299
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079848
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079847
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3124454
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3124453
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7391612
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7391609
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3008873
Quantity 100 μg
Datasheet Datasheet
Reactivity Pig
Source Yeast
Validations
Cat. No. ABIN7479001
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1475408
Quantity 1 mg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1459540
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our F12 蛋白

Baeriswyl, Calzavarini, Chen, Zorzi, Bologna, Angelillo-Scherrer, Heinis: "A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation." in: ACS chemical biology, Vol. 10, Issue 8, pp. 1861-70, (2015) (PubMed).

Rentero Rebollo, Sabisz, Baeriswyl, Heinis: "Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides." in: Nucleic acids research, Vol. 42, Issue 22, pp. e169, (2014) (PubMed).

Aliases for F12 蛋白

coagulation factor XII (F12) 蛋白
coagulation factor XII (Hageman factor) (F12) 蛋白
FXII 蛋白
HAE3 蛋白
HAEX 蛋白
HAF 蛋白
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