DKK1 Protein (AA 32-266) (His tag)
(2 references)-
- 抗原 See all DKK1 蛋白
- DKK1 (Dickkopf Homolog 1 (DKK1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 32-266
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This DKK1 protein is labelled with His tag.
- 序列
- AA 32-266
- 产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.8 kDa. The protein migrates as 40-46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product DKK1 蛋白
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Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His-Avi Tag,Biotin)
DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His tag)DKK1 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-142) protein (Fc-Avi Tag)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (C-Term) protein (Fc-Avi Tag,Biotin)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 178-266) protein (Fc-Avi Tag)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (N-Term) protein (Fc-Avi Tag,Biotin)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 1-272) protein (His tag)DKK1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Dickkopf Homolog 1 (DKK1) (AA 1-266) protein (GST tag)DKK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 81-180) protein (GST tag)DKK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 1-242) protein (GST tag)DKK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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: "Neuropeptide Y enhances proliferation and prevents apoptosis in rat bone marrow stromal cells in association with activation of the Wnt/β-catenin pathway in vitro." in: Stem cell research, Vol. 21, pp. 74-84, (2018) (PubMed).
: "The Effect of C-X-C Motif Chemokine 13 on Hepatocellular Carcinoma Associates with Wnt Signaling." in: BioMed research international, Vol. 2015, pp. 345413, (2015) (PubMed).
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: "Neuropeptide Y enhances proliferation and prevents apoptosis in rat bone marrow stromal cells in association with activation of the Wnt/β-catenin pathway in vitro." in: Stem cell research, Vol. 21, pp. 74-84, (2018) (PubMed).
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- 抗原
- DKK1 (Dickkopf Homolog 1 (DKK1))
- 别名
- Dkk-1 (DKK1 产品)
- 别名
- DKK-1 Protein, SK Protein, AI414495 Protein, SGY Protein, SGY-1 Protein, SGY1 Protein, Soggy Protein, mSgy Protein, dkk1 Protein, dkk Protein, dkk-1 Protein, xdkk1 Protein, Xdkk-1 Protein, Dickkopf1 Protein, dickkopf-1 Protein, mdkk-1 Protein, dkk1-A Protein, dickkopf WNT signaling pathway inhibitor 1 Protein, dickkopf like acrosomal protein 1 Protein, dickkopf-related protein 1 Protein, dickkopf-like 1 Protein, dickkopf WNT signaling pathway inhibitor 1b Protein, dickkopf protein Protein, dickkopf WNT signaling pathway inhibitor 1 S homeolog Protein, DKK1 Protein, Dkk1 Protein, DKKL1 Protein, LOC100228789 Protein, Dkkl1 Protein, dkk1b Protein, dkk1 Protein, dickkopf Protein, dkk1.S Protein
- 背景
- Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.
- 分子量
- 26.6 kDa
- NCBI登录号
- NP_036374
- 途径
- WNT signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
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