TNFRSF4 Protein (AA 29-214) (Fc Tag)
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- 抗原 See all TNFRSF4 蛋白
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 29-214
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宿主
- 人, 小鼠
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资源
- HEK-293 Cells
- 标记
- This TNFRSF4 protein is labelled with Fc Tag.
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds to human and mouse OX40L.
- 交叉反应
- 人, 小鼠
- 产品特性
- Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF4 蛋白
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Blocks T cell proliferation induced by CD134L.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 50 μL sterile water.
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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- 抗原
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- 别名
- OX40 (TNFRSF4 产品)
- 别名
- TNFRSF4 Protein, ACT35 Protein, CD134 Protein, Ly-70 Protein, Ox40 Protein, TXGP1L Protein, Txgp1 Protein, OX40 Protein, TNF receptor superfamily member 4 Protein, tumor necrosis factor receptor superfamily, member 4 Protein, TNFRSF4 Protein, Tnfrsf4 Protein
- 背景
- OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
- 分子量
- ~70kDa (SDS-PAGE)
- UniProt
- P43489
- 途径
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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