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抗Human NCF1 抗体:
抗Mouse (Murine) NCF1 抗体:
抗Rat (Rattus) NCF1 抗体:
Human Monoclonal NCF1 Primary Antibody for IF, WB - ABIN967919
Ago, Nunoi, Ito, Sumimoto: Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating in The Journal of biological chemistry 1999
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Human Monoclonal NCF1 Primary Antibody for IF, WB - ABIN967918
Chanock, el Benna, Smith, Babior: The respiratory burst oxidase. in The Journal of biological chemistry 1994
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Human Polyclonal NCF1 Primary Antibody for WB - ABIN2801889
Volpp, Nauseef, Donelson, Moser, Clark: Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Mouse (Murine) Polyclonal NCF1 Primary Antibody for IHC, ELISA - ABIN1531722
Lee, Ko, Jeong, Park, Kim: β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. in Journal of neuroinflammation 2015
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Human Polyclonal NCF1 Primary Antibody for IF (p), IHC (p) - ABIN1385194
Chen, Ye, Zhang, Tang, Li, Lu, Wu, Yu, Kou: Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils. in International journal of molecular sciences 2016
Human Polyclonal NCF1 Primary Antibody for IF (p), IHC (p) - ABIN1387732
Almajdoob, Hossain, Anand-Srivastava: Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling. in Vascular pharmacology 2018
Human Polyclonal NCF1 Primary Antibody for IHC, ELISA - ABIN1531718
Kröller-Schön, Steven, Kossmann, Scholz, Daub, Oelze, Xia, Hausding, Mikhed, Zinßius, Mader, Stamm, Treiber, Scharffetter-Kochanek, Li, Schulz, Wenzel, Münzel, Daiber: Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species - studies in white blood cells and in animal models. in Antioxidants & redox signaling 2013
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Mouse (Murine) Polyclonal NCF1 Primary Antibody for ELISA, IF - ABIN1586076
Kim, Ryu, Kang: Status epilepticus induces vasogenic edema via tumor necrosis factor-α/ endothelin-1-mediated two different pathways. in PLoS ONE 2014
Human Polyclonal NCF1 Primary Antibody for ELISA, IHC (p) - ABIN256632
Davidson-Moncada, Lopez-Lluch, Segal, Dekker: Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils. in The Biochemical journal 2002
Mouse (Murine) Polyclonal NCF1 Primary Antibody for ELISA, WB - ABIN4338257
Roos, Kuhns, Maddalena, Bustamante, Kannengiesser, de Boer, van Leeuwen, Köker, Wolach, Roesler, Malech, Holland, Gallin, Stasia: Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update). in Blood cells, molecules & diseases 2010
patients with hereditary p47phox deficiency show reduced platelet activation suggesting a role for this Nox cytosolic subunit in platelet activation.
Decreased and increased copy numbers of NCF1 predispose to and protect against SLE.
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (显示 HCK 抗体)-dependent activation of PKCdelta (显示 PKCd 抗体), which stimulates PKCgamma (显示 PRKCG 抗体), resulting in translocation of phosphorylated p47(phox).
There was an increased frequency of the NCF1-339 T allele in patients with systemic lupus erythematosus. The NCF1-339 T allele reduced extracellular ROS (显示 ROS1 抗体) production in neutrophils and led to an increase expression of type 1 interferon (显示 IFNA 抗体)-regulated genes.
Skeletal muscle protein expression of the NADPH oxidase (显示 NOX1 抗体) subunits p22(phox (显示 CYBA 抗体)), p47(phox), and p67(phox (显示 NCF2 抗体)) was increased in obese relative to lean subjects, where p22(phox (显示 CYBA 抗体)) and p67(phox (显示 NCF2 抗体)) expression was attenuated by exercise training in obese subjects.
A novel role for Spns2 (显示 SPNS2 抗体) and S1P1 (显示 S1PR1 抗体)&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.
Study provides evidence for a novel PKC-zeta (显示 PRKCZ 抗体) to p47phox interaction that is required for cell transformation from blebbishields and ROS (显示 ROS1 抗体) production in cancer cells.
Overexpression of p47phox is associated with increased migration/metastasis rate in melanoma.
A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (显示 NOX1 抗体) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population
Data show that diphenylene iodonium (DPI) and apocynin can reduce hyperoxia-induced reactive oxygen species (ROS) production by decreasing the translocation and level of NADPH Oxidase p47phox.
Results show that Ncf1 is not needed during juvenility to protect from autoimmune arthritis later on, but conditional Ncf1 suppresses arthritis even if activated after the disease priming. The study presents in vivo evidence that Ncf1/reactive oxygen species-regulated mechanisms are different in priming than in the effector phase.
we used the Ang II (显示 AGT 抗体) infused hph-1 (显示 EGLN2 抗体) mice to examine the roles of NOX isoforms in the development of AAA (显示 AAAS 抗体). We generated double mutants of hph-1 (显示 EGLN2 抗体)-NOX1 (显示 NOX1 抗体), hph-1 (显示 EGLN2 抗体)-NOX2 (显示 CYBB 抗体), hph-1 (显示 EGLN2 抗体)-p47phox, and hph-1 (显示 EGLN2 抗体)-NOX4 (显示 NOX4 抗体)
Mice bearing point mutation in the Ncf1-gene develop fewer osteoclasts after ovariectomy (ovx) than wild-type mice. However, irrespective of genotype, bone mineral density decreases after ovx, indicating that a compensatory mechanism retains bone degradation after ovx.
The authors demonstrated a significant role of the host NADPH oxidase (显示 NOX1 抗体) in promoting chronic inflammatory pathology in the oviduct following chlamydial infection.
data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.
Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (显示 CD4 抗体)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.
The Park7 (显示 PARK7 抗体) binds to p47(phox), a subunit of the NADPH oxidase (显示 NOX1 抗体), to promote NADPH oxidase (显示 NOX1 抗体)-dependent production of ROS (显示 ROS1 抗体).
p47(phox)-dependent NADPH oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury
p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.
These findings suggest that a p47(phox)-dependent NAD(P)H (显示 NQO1 抗体) oxidase mediates the increase in diaphragm oxidants and contractile dysfunction in chronic heart failure.
Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.
A p47(phox) and Src kinase (显示 CSK 抗体) activation of peroxide production by Nox2 (显示 CYBB 抗体) appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (显示 PKC 抗体).
Angiotensin II inhibits the Na+/K+ pump via PKC (显示 PKC 抗体)-dependent activation of NADPH oxidase (显示 NOX1 抗体) subunits.
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
47 kDa autosomal chronic granulomatous disease protein
, 47 kDa neutrophil oxidase factor
, NADPH oxidase organizer 2
, SH3 and PX domain-containing protein 1A
, neutrophil NADPH oxidase factor 1
, neutrophil cytosol factor 1
, neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
, nox organizer 2
, nox-organizing protein 2
, NADPH oxidase subunit (47 kD)
, NADPH oxidase subunit (47kDa)
, phagocyte oxidase 47 kDa
, neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1)
, NADPH oxidase p47-phox
, predicted neutrophil cytosolic factor 1