The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Yamashita, Izumi, Kashima, Ohnishi, Saari, Katsuhata, Muramatsu, Morita, Iwamatsu, Hachiya, Kurata, Hirano, Anderson, Ohno: "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay." in: Genes & development, Vol. 23, Issue 9, pp. 1091-105, (2009) (PubMed).
Mazza, Segref, Mattaj, Cusack: "Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex." in: The EMBO journal, Vol. 21, Issue 20, pp. 5548-57, (2002) (PubMed).
Calero, Wilson, Ly, Rios-Steiner, Clardy, Cerione: "Structural basis of m7GpppG binding to the nuclear cap-binding protein complex." in: Nature structural biology, Vol. 9, Issue 12, pp. 912-7, (2002) (PubMed).
Aliases for NCBP2 抗体
cap binding protein 20 (Cbp20) 抗体 nuclear cap binding protein subunit 2 (Ncbp2) 抗体 nuclear cap binding protein subunit 2 (ncbp2) 抗体 nuclear cap binding protein subunit 2 (NCBP2) 抗体 nuclear cap binding protein subunit 2, 20kDa (NCBP2) 抗体 nuclear cap binding protein subunit 2 L homeolog (ncbp2.L) 抗体 nuclear cap-binding protein subunit 2 (Cbp20) 抗体 CAP-binding protein 20 (CBP20) 抗体 Nuclear cap-binding protein subunit 2 (ncbp-2) 抗体 20kDa 抗体 5930413E18Rik 抗体 AA536802 抗体 AI843301 抗体 ATCBP20 抗体 C79367 抗体 CAP-binding protein 20 抗体 CBC2 抗体 CBP20 抗体 CG12357 抗体 CHUNP6917 抗体 Dmel\\CG12357 抗体 MLN1.12 抗体 MLN1_12 抗体 Ncbp2 抗体 NIP1 抗体 zgc:92592 抗体