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Sec5 concentrates at the sub-apical complex, indicating a role for Sec5 in the polarized epithelium.
Germline clones of sec5 possess defects in membrane addition and the posterior positioning of the oocyte.
Sec5, Sec6 (显示 EXOC3 抗体) and Sec8 (显示 EXOC4 抗体) act as a complex, each member dependent on the others for proper localization and function
Rab11 forms a complex with Sec5. Sec5 interacts with Sec6 suggesting the exocyst is a Rab11 effector that facilitates protein transport to the apical rhabdomere in Drosophila photoreceptors
The Drosophila exocyst component sec5 in epithelial cells results in DE-Cad (显示 CAD 抗体) accumulation in an enlarged Rab11 (显示 RAB11A 抗体) recycling endosomal compartment and inhibits DE-Cad (显示 CAD 抗体) delivery to the membrane.
data suggest that the induction of SGK1 (显示 SGK1 抗体) through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 (显示 ARHGEF2 抗体) interactions, which promote GEF-H1 (显示 ARHGEF2 抗体) targeting to adhesion sites.
Exocyst sec5 regulates exocytosis of newcomer insulin (显示 INS 抗体) granules underlying biphasic insulin (显示 INS 抗体) secretion.
We identified interactions between RalA (显示 rala 抗体) and its effectors sec5 and exo84 (显示 EXO84 抗体) in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells.
Data show that Mc1R (显示 MSHR 抗体), HERC2 (显示 HERC2 抗体), IRF4 (显示 IRF4 抗体), TYR (显示 TYR 抗体) and EXOC2 are ranked highest in hair color prediction analysis.
shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells.
SEC5 has been identified as a binding partner of deafness locus putative guanine nucleotide exchange factor (显示 RASGRF1 抗体).
evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral (显示 rala 抗体) GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 (显示 EXO84 抗体)
These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB (显示 Ralb 抗体)/Sec5 effector complex as a component of TBK1 (显示 TBK1 抗体)-dependent innate immune signaling.
Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral (显示 rala 抗体) GTPases, which control association between Sec5 and paxillin (显示 PXN 抗体).
the structure of the Ral (显示 rala 抗体)-binding domain of Sec5
SEC5a copurifies in a high molecular mass fraction of 900 kD, and functions as a subunit in a exocyst complex that plays important roles in morphogenesis.
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants.
, exocyst complex component 2
, SEC5-like 1
, exocyst complex component Sec5
, SEC5 homolog