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New Floxed Pde1b x CreCMV global knockout (KO) mice demonstrate depression-like behavioral resistance separate from stress-related effects.
Pde1b knock-out mice exhibited decreased tail suspension test and forced swim test immobilization; a model for depression.
These results prove that the kinetic properties of PDE (显示 TWIST1 蛋白) isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2 (显示 CA2 蛋白)+]i.
Data suggest a role for PDE1B in locomotor responses to psychostimulants through modulation of DARPP32 (显示 PPP1R1B 蛋白)-dependent pathways; however, this modulation does not necessarily impact other behaviors, such as anxiety or learning.
The present studies demonstrate increased striatal dopamine turnover in PDE1B knockout mice associated with increased baseline motor activity and an exaggerated locomotor response to dopaminergic stimulants such as methamphetamine and amphetamine.
The c.1618G>A, p.Gly540Ser substitution in CNGA3 (显示 CNGA3 蛋白) was identified as the causative mutation for a novel form of ACHM in Awassi sheep. Gene augmentation therapy restored vision in the affected sheep. This novel mutation provides a large-animal model that is valid for most human CNGA3 (显示 CNGA3 蛋白) ACHM patients; the majority of them carry missense rather than premature-termination mutations.
The PDE1B gene is a candidate gene for carcass traits of beef cattle.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
63 kDa Cam-PDE
, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
, cam-PDE 1B
, phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa
, phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa
, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
, calmodulin-stimulated phosphodiesterase PDE1B1
, presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B
, anti-oxidant protein 2
, cyclic nucleotide phosphodiesterase (CaM-PDE)
, phosphodiesterase 1B, Ca2+calmodulin dependent
, phosphodiesterase 1B1 Ca2+-calmodulin dependent 63 kDa
, phosphodiesterase IB calmodulin-dependent