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抗Human ANAPC5 抗体:
抗Mouse (Murine) ANAPC5 抗体:
抗Rat (Rattus) ANAPC5 抗体:
Human Polyclonal ANAPC5 Primary Antibody for IP, WB - ABIN188629
Tran, Kamil, Coen, Spector et al.: Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated ... in Journal of virology 2010
Show all 2 Pubmed References
coexpression of APC5 and Axin (显示 AXIN1 抗体) genes significantly downregulated Wnt (显示 WNT2 抗体) signaling in human SW480 CRC (显示 CALR 抗体) cells and inhibited cell growth.
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 (显示 ANAPC4 抗体) subunits and does not require UL97-mediated phosphorylation of Cdh1 (显示 CDH1 抗体).
Studies indicate that APC (显示 APC 抗体)/C(Cdh1 (显示 CDH1 抗体)) is required to maintain genomic stability.
Results show that Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) element of platelet-derived growth factor 2 mRNA.
APC5 and APC7 (显示 ANAPC7 抗体) suppress E1A (显示 BCKDHA 抗体)-mediated transformation in a CBP/p300 (显示 CREBBP 抗体)-dependent manner, indicating that these components of the APC (显示 APC 抗体)/C may be targeted during cellular transformation
The anaphase-promoting complex protein 5 (显示 CAPS 抗体) (AnapC5) associates with A20 (显示 TNFAIP3 抗体) and inhibits IL-17 (显示 IL17A 抗体)-mediated signal transduction.
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
anaphase-promoting complex subunit 5
, cyclosome subunit 5
, anaphase promoting complex subunit 5
, anaphase-promoting complex subunit 5-like
, 20S cyclosome/APC complex protein apc5