ANAPC5 产品
(Anaphase Promoting Complex Subunit 5 (ANAPC5))
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This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008].
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Featured ANAPC5 Categories
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Latest Publications for our ANAPC5 Products
: "Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a." in: PLoS pathogens, Vol. 8, Issue 7, pp. e1002789, (2012) (PubMed).: "Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated ..." in: Journal of virology, Vol. 84, Issue 20, pp. 10832-43, (2010) (PubMed).
: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, (2008) (PubMed).
: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).
: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).
: "Mitotic regulation of the human anaphase-promoting complex by phosphorylation." in: The EMBO journal, Vol. 22, Issue 24, pp. 6598-609, (2003) (PubMed).
: "Identification of a cullin homology region in a subunit of the anaphase-promoting complex." in: Science (New York, N.Y.), Vol. 279, Issue 5354, pp. 1219-22, (1998) (PubMed).
Synonyms and alternative names related to ANAPC5
anaphase promoting complex subunit 5 (ANAPC5), anaphase promoting complex subunit 5 (anapc5), anaphase-promoting complex subunit 5 (LOC100093215), anaphase promoting complex subunit 5 L homeolog (anapc5.L), anaphase-promoting complex subunit 5 (Anapc5), anaphase-promoting complex subunit (AT1G06590), anaphase-promoting complex subunit Apc5 (apc5), anaphase promoting complex subunit 5 (Anapc5), 2510006G12Rik, AA408751, AA536819, AA986414, ANAPC5, Anpc5, APC5, DDBDRAFT_0206386, DDBDRAFT_0234269, DDB_0206386, DDB_0234269, F12K11.7, F12K11_7, MGC89697, wu:fb75a09, zgc:55800Protein level used designations for ANAPC5
- anaphase-promoting complex subunit 5
- cyclosome subunit 5
- APC5
- anaphase promoting complex subunit 5
- anaphase-promoting complex subunit 5-like
- 20S cyclosome/APC complex protein apc5
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