Amylin/DAP 产品
(Islet Amyloid Polypeptide (IAPP))
Categories
Amylin, also known as islet amyloid polypeptide (IAPP), is a peptide hormone primarily produced by pancreatic beta cells. It plays several important roles in regulating glucose metabolism and satiety. Here are the major cellular mechanisms in which amylin is involved:
- Glucose Regulation and Delayed Absorption: Amylin helps regulate blood glucose levels by slowing down the emptying of the stomach, delaying glucose absorption, and reducing post-meal blood sugar spikes.
- Appetite Control and Satiety: Amylin acts in the brain to induce feelings of fullness and reduce food intake, contributing to appetite control and weight management.
- Inhibition of Glucagon and Insulin Sensitivity: Amylin inhibits glucagon secretion, helping to maintain glucose homeostasis, and may enhance insulin sensitivity in peripheral tissues, aiding in overall metabolic health.
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Featured Amylin/DAP Categories
Amylin/DAP 抗体
High quality antibodies with extensive validation data.
Amylin/DAP ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Amylin/DAP 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Amylin/DAP 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7426055
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6259921
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7157084
Quantity
100 μg
Datasheet
Datasheet
Recommended Amylin/DAP ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957220
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968064
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968062
Quantity
96 tests
Datasheet
Datasheet
Recommended Amylin/DAP 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123638
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307318
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7392188
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Amylin/DAP Products
: "Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment." in: PLoS ONE, Vol. 11, Issue 3, pp. e0149409, (2016) (PubMed).: "Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120479, (2015) (PubMed).
: "The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells." in: PLoS ONE, Vol. 10, Issue 7, pp. e0133263, (2015) (PubMed).
: "Rational design of potent domain antibody inhibitors of amyloid fibril assembly." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 49, pp. 19965-70, (2012) (PubMed).
: "Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway." in: The American journal of pathology, Vol. 176, Issue 2, pp. 861-9, (2010) (PubMed).
: "Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition." in: Pancreas, Vol. 39, Issue 6, pp. 843-6, (2010) (PubMed).
: "Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus." in: Acta diabetologica, Vol. 47, Issue 3, pp. 265-70, (2010) (PubMed).
: "Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey." in: Veterinary pathology, Vol. 45, Issue 1, pp. 67-72, (2008) (PubMed).
: "Amyloid oligomers in diabetic and nondiabetic human pancreas." in: Translational research : the journal of laboratory and clinical medicine, Vol. 153, Issue 1, pp. 24-32, (2008) (PubMed).
: "Cloning and expression of human islet amyloid polypeptide in cultured cells." in: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 622-8, (2007) (PubMed).
Synonyms and alternative names related to Amylin/DAP
islet amyloid polypeptide (IAPP), islet amyloid polypeptide (Iapp), Amylin, DAP, IAP, LOC100230121Protein level used designations for Amylin/DAP
- Islet amyloid polypeptide (diabetes-associated peptide; amylin)
- amylin
- diabetes-associated peptide
- insulinoma amyloid peptide
- DAP
- islet amyloid polypeptide
- amyloid protein
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