Aneurysm, Intracranial Berry 3 抗体 (AA 22-146)
Cited in 1 publication.
The 兔 多克隆 anti-Aneurysm, Intracranial Berry 3 antibody (ABIN2668550) specifically detects Aneurysm, Intracranial Berry 3 in IHC 和 WB.
The antibody is reactive with 人 和 小鼠 samples.
(1 reference)
产品编号 ABIN2668550
发货至:
中国
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Quick Overview for Aneurysm, Intracranial Berry 3 抗体 (AA 22-146) (ABIN2668550)
抗原
Aneurysm, Intracranial Berry 3 (ANIB3)
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
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抗原表位
- AA 22-146
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原理
- AIB3 antibody (pAb)
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纯化方法
- Affinity Purified
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免疫原
- This AIB3 antibody was raised against a recombinant protein corresponding to amino acids 22-146 of mouse AIB3.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified IgG in 70 mM Tris-HCl ( pH 8), 105 mM NaCl, 70 mM glycine, 30 % glycerol, 0.035 % sodium azide and 0.05 % BSA.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation ..." in: Cancer research, Vol. 64, Issue 19, pp. 7169-77, (2004) (PubMed).
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- Aneurysm, Intracranial Berry 3 (ANIB3)
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别名
- AIB3
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物质类
- Chemical
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背景
- AIB3 (Amplified in Breast Cancer 3, Nuclear Receptor Coactivator 6, NCoA6) is a chromatin-associated protein that interacts with nuclear hormone receptors (antibodies, kits and proteins) to modify their activity as transcriptional activators. AIB3 / NCoA6 was originally isolated as a ligand-dependent nuclear receptor interacting protein. It is a co-activator that directly binds nuclear receptors and stimulates their transcriptional activity in a hormone-dependent fashion. AIB3 is a multifunctional co-activator necessary for transcriptional activation of a wide spectrum of target genes. AIB3 is involved in growth, development, wound healing and maintenance of energy homeostasis. It can enhance the transcriptional activation of a variety of transcription factors and also associates with a number of important regulators of transcription including CBP and p300. AIB3 / NCoA6 is a component of at least three distinct MLL complexes, suggesting that AIB3 plays a fundamental role in transcriptional activation by modulating chromatin structure through histone methylation. AIB3 may also be involved in the co-activation of the NF-kappa-B pathway. It is amplified and overexpressed in breast, colon and lung cancers. AIB3 function is essential in mammalian development as AIB3 null embryos do not survive. Additionally, AIB null spontaneously undergo apoptosis, indicating that AIB3 has anti-apoptotic and pro-survival functions.
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分子量
- 250 kDa
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基因ID
- 23054
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NCBI登录号
- NP_062799
抗原
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