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ITK 产品

(IL2-Inducible T-Cell Kinase (ITK))

Categories

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008].

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Featured ITK Categories

ITK 抗体

High quality antibodies with extensive validation data.

ITK ELISA试剂盒

Reliable ELISA kits for a wide range of species.

ITK 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ITK 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application WB, ELISA, IHC, FACS, IF
Validations
  • (6)
Cat. No. ABIN1589997
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, ICC, FACS
Validations
  • (2)
  • (5)
Cat. No. ABIN969222
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (5)
Cat. No. ABIN184605
Quantity 100 μg
Datasheet Datasheet

Recommended ITK ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956705
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4886150
Quantity 96 tests
Datasheet Datasheet

Recommended ITK 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect cells (Sf9)
Validations
  • (2)
Cat. No. ABIN5570598
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123402
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308231
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our ITK Products

Huck, Feyen, Niehues, Rüschendorf, Hübner, Laws, Telieps, Knapp, Wacker, Meindl, Jumaa, Borkhardt: "Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation." in: The Journal of clinical investigation, Vol. 119, Issue 5, pp. 1350-8, (2009) (PubMed).

Kogina, Shoda, Yamaguchi, Tsuno, Takahashi, Fujio, Yamamoto: "Tacrolimus differentially regulates the proliferation of conventional and regulatory CD4(+) T cells." in: Molecules and cells, Vol. 28, Issue 2, pp. 125-30, (2009) (PubMed).

Graves, Siroux, Guerra, Klimecki, Martinez: "Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33." in: The Journal of allergy and clinical immunology, Vol. 116, Issue 3, pp. 650-6, (2005) (PubMed).

Wilcox, Berg: "Itk phosphorylation sites are required for functional activity in primary T cells." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37112-21, (2003) (PubMed).

Brazin, Mallis, Fulton, Andreotti: "Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 4, pp. 1899-904, (2002) (PubMed).

Perez-Villar, ODay, Hewgill, Nadler, Kanner: "Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)." in: International immunology, Vol. 13, Issue 10, pp. 1265-74, (2001) (PubMed).

Hawkins, Marcy: "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity." in: Protein expression and purification, Vol. 22, Issue 2, pp. 211-9, (2001) (PubMed).

Perez-Villar, Kanner: "Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6435-41, (2000) (PubMed).

Bunnell, Diehn, Yaffe, Findell, Cantley, Berg: "Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade." in: The Journal of biological chemistry, Vol. 275, Issue 3, pp. 2219-30, (2000) (PubMed).

Prahlad, Yoon, Moir, Vale, Goldman: "Rapid movements of vimentin on microtubule tracks: kinesin-dependent assembly of intermediate filament networks." in: The Journal of cell biology, Vol. 143, Issue 1, pp. 159-70, (1998) (PubMed).

Synonyms and alternative names related to ITK

IL2 inducible T cell kinase (Itk), IL2 inducible T-cell kinase (ITK), IL2-inducible T-cell kinase (Itk), Emt, EMT, LPFS1, LYK, PSCTK2, Tcsk, Tsk

Protein level used designations for ITK

  • T-cell-specific kinase
  • interleukin-2-inducible T cell kinase
  • kinase TLK
  • tyrosine-protein kinase ITK/TSK
  • IL-2-inducible T cell kinase
  • IL-2-inducible T-cell kinase
  • homolog of mouse T-cell itk/tsk
  • interleukin-2-inducible T-cell kinase
  • kinase EMT
  • tyrosine-protein kinase LYK
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