IRF6 产品
(Interferon Regulatory Factor 6 (IRF6))
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This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011].
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Featured IRF6 Categories
Recommended IRF6 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human, Rat
Application
WB, IHC, IF, FACS, IHC (p)
Validations
- (14)
Cat. No.
ABIN1498901
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (4)
Cat. No.
ABIN184730
Quantity
100 μg
Datasheet
Datasheet
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Mouse
Application
WB, IHC, ICC
Validations
- (4)
Cat. No.
ABIN1859476
Quantity
100 μL
Datasheet
Datasheet
Recommended IRF6 ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967757
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6205230
Quantity
96 tests
Datasheet
Datasheet
Recommended IRF6 蛋白
Product
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Source
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Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308094
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308096
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3082086
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our IRF6 Products
: "IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages." in: Endocrinology, Vol. 158, Issue 9, pp. 2837-2847, (2017) (PubMed).: "TGFβ3 regulates periderm removal through ΔNp63 in the developing palate." in: Journal of cellular physiology, Vol. 230, Issue 6, pp. 1212-25, (2015) (PubMed).
: "Interferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells." in: The Journal of biological chemistry, Vol. 289, Issue 28, pp. 19758-68, (2014) (PubMed).
: "Smad4-Irf6 genetic interaction and TGF?-mediated IRF6 signaling cascade are crucial for palatal fusion in mice." in: Development (Cambridge, England), Vol. 140, Issue 6, pp. 1220-30, (2013) (PubMed).
: "Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 33, pp. 13710-5, (2011) (PubMed).
: "A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias." in: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1570-7, (2010) (PubMed).
: "Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2235-43, (2008) (PubMed).
: "Interferon regulatory factor 6 (IRF6) is associated with oral-facial cleft in individuals that originate in South America." in: American journal of medical genetics. Part A, Vol. 143A, Issue 17, pp. 2075-8, (2007) (PubMed).
: "Suggestive linkage to a neighboring region of IRF6 in a cleft lip and palate multiplex family." in: American journal of medical genetics. Part A, Vol. 143A, Issue 22, pp. 2716-21, (2007) (PubMed).
: "Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. ..." in: Nature genetics, Vol. 32, Issue 2, pp. 285-9, (2002) (PubMed).
Synonyms and alternative names related to IRF6
interferon regulatory factor 6 (IRF6), interferon regulatory factor 6 (irf6), interferon regulatory factor 6 S homeolog (irf6.S), interferon regulatory factor 6 (Irf6), AI876454, DKFZp469E012, E230028I05Rik, IRF6, lps, LPS, mirf6, ofc6, OFC6, pit, PIT, pps, PPS, PPS1, vws, VWS, VWS1, xIRF-6, zgc:63500Protein level used designations for IRF6
- interferon regulatory factor 6
- interferon regulatory factor 6-like
- IRF-6
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