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Low IGFBP7 expression is associated with Gastric Cancer.
Reduced RNA editing of IGFBP7 gene is associated with psoriasis.
Urine levels of IGFBP7 (and TIMP2 (显示 TIMP2 蛋白)) are predictive for acute kidney injury following cardiac surgical procedures.
IGFBPrP1 transfection inhibited cell growth, and induced G1 phase arrest and cellular senescence in HEC1A cells while gene silencing presented the adverse functional changes.
Serum IGFBP7 levels were raised during acute exacerbation in COPD (显示 ARCN1 蛋白) patients.
epithelial cells and leukocytes from the urinary sediment. CONCLUSION: The gene expression pattern of IGFBP7 and TIMP-2 (显示 TIMP2 蛋白) from urinary sediment, which contains desquamated renal tubular epithelial cells, did not correlate with [IGFBP7]x[TIMP-2 (显示 TIMP2 蛋白)] protein, indicating that IGFBP7 and TIMP-2 (显示 TIMP2 蛋白) measured in the NephroCheck(R) test originated predominantly from intact but stressed cells of the kidney itself
In patients with heart failure with preserved ejection fraction, IGFBP7 may be a novel biomarker of diastolic function and exercise capacity.
High IGFBP7 expression is associated with acute kidney injury.
NEAT1-associated paraspeckle proteins P54nrb (显示 NONO 蛋白) and PSF have been reported as positive regulators of c-Myc (显示 MYC 蛋白) translation through interaction with c-Myc (显示 MYC 蛋白) IRES
study of polymorphisms of the porcine IGFBP7 promoter region in different pig breeds
analysis of how A-to-I RNA editing of the IGFBP7 transcript increases during aging in porcine brain tissues
Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma
Study shows that IGFBP7 contributes significantly to mesenchymal stromal cells (MSC (显示 MSC 蛋白))-mediated immune modulation, as is shown by decreasing ability of IGFBP7 knockdown in MSCs to restore proliferation and cytokine production in T-cells.
data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases
Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals.
Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs (显示 NR2E3 蛋白)) and its regulation depends on TAp63 isoform.
results show that Smarcb1 (显示 SMARCB1 蛋白) is required for transcriptional activation of Igfbp7 and show that re-introduction of Igfbp7 alone can hinder tumor development; results define a novel mechanism for Smarcb1 (显示 SMARCB1 蛋白)-mediated tumorigenesis
a model whereby IGFBP7 binds to unoccupied IGF1R (显示 IGF1R 蛋白) and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival.
IGFBP7 has a novel role in mouse uterus: it is regulating uterine receptivity through Th1 (显示 HAND1 蛋白)/Th2 lymphocyte balance and decidualization.
fear extinction-induced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons
Results demonstrate that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A (显示 VEGFA 蛋白).
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
insulin-like growth factor-binding protein 7
, IGF-binding protein 7
, PGI2-stimulating factor
, prostacyclin-stimulating factor
, tumor-derived adhesion factor