IGFBP7
(Insulin-Like Growth Factor Binding Protein 7 (IGFBP7))
蛋白类型
Recombinant
产品特性
AA 30-282
宿主
人
资源
HEK-293 Cells
标记
This IGFBP7 protein is labelled with His tag.
序列
AA 30-282
产品特性
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Insulin-like growth factor-binding protein 7 (IGFBP7) is also known as IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, prostacyclin-stimulating factor and tumor-derived adhesion factor, which contains one Ig-like C2-type (immunoglobulin-like) domain, one IGFBP N-terminal domain and one Kazal-like domain. The major function of IGFBP7 is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with high affinity except for IGF-I and IGF-II.IGFBP7 also stimulates cell adhesion. Furthermore, IGFBP7 is implicated in some cancers.