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Human TGFB1 Protein expressed in CHO Cells - ABIN809732
Farges, Romeas, Melin, Pin, Lebecque, Lucchini, Bleicher, Magloire: TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. in Journal of dental research 2003
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Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039656
Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997
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Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039657
Loeys, Schwarze, Holm, Callewaert, Thomas, Pannu, De Backer, Oswald, Symoens, Manouvrier, Roberts, Faravelli, Greco, Pyeritz, Milewicz, Coucke, Cameron, Braverman, Byers, De Paepe, Dietz: Aneurysm syndromes caused by mutations in the TGF-beta receptor. in The New England journal of medicine 2006
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Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039655
Benke, Ágg, Szilveszter, Tarr, Nagy, Pólos, Daróczi, Merkely, Szabolcs: The role of transforming growth factor-beta in Marfan syndrome. in Cardiology journal 2013
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Human TGFB1 Protein expressed in HEK-293 Cells - ABIN805198
Huang, Zhao, Fields, Ransohoff, Zhou: Imatinib attenuates skeletal muscle dystrophy in mdx mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
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Rat (Rattus) TGFB1 Protein expressed in Escherichia coli (E. coli) - ABIN1081012
Elfayomy, Almasry, El-Tarhouny, Eldomiaty: Human umbilical cord blood-mesenchymal stem cells transplantation renovates the ovarian surface epithelium in a rat model of premature ovarian failure: Possible direct and indirect effects. in Tissue & cell 2016
Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188
Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983
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Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2733505
Wang, Reece, Yang: Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. in American journal of obstetrics and gynecology 2015
Following Schistosoma exposure, TSP-1 (显示 THBS1 蛋白) levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 (显示 THBS1 蛋白) inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development.
TGFbeta1 reduced complex IV protein MTCO1 abundance in both myoblasts and myotubes.
TGF-beta1 expression is regulated by PlncRNA-1 in breast cancer.
Elevated AhR (显示 AHR 蛋白) expression may be involved in the progression of tissue remodeling in chronic rhinosinusitis without nasal polyp without allergic rhinitis similar to TGF-beta1 expression
Overall, these findings suggest a more dominant role for SMAD3 (显示 SMAD3 蛋白) and SMAD4 (显示 SMAD4 蛋白) than SMAD2 (显示 SMAD2 蛋白) in TGFbeta-induced chondrogenesis of human bone marrow-derived mesenchymal stem cells.
High TGF beta expression is associated with Chronic Periodontitis.
Fewer TIMP-2 (显示 TIMP2 蛋白), Hsp70 (显示 HSP70 蛋白) and TGF-beta1 immunoreactive cells in younger individuals and increased expression of Hsp70 (显示 HSP70 蛋白) in elderly individuals demonstrated the influence of aging in lung remodeling
Data show that TGFbeta1-mediated EMT (显示 ITK 蛋白) involves CD44 (显示 CD44 蛋白) splice isoform switching in ovarian cancer cells.
Gene silencing experiments of MLL4 and the subunits PA1 and PTIP confirm TGF-beta-specific genes to be regulated by the MLL4 complex, which links TGF-beta signaling to transcription regulation by the MLL4 methyltransferase complex.
TGF-beta1 is significantly overexpressed in tumor tissue samples of clear cell Renal cell carcinoma (显示 MOK 蛋白) patients. TGF-beta1 up-regulation could be responsible for the high levels of NNMT (显示 NNMT 蛋白) observed in clear cell Renal cell carcinoma (显示 MOK 蛋白) tissues.
TGF-beta1 stimulated lubricin (显示 PRG4 蛋白) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (显示 PRG4 蛋白) much higher compared with twice-a-week treatment.
hypoxia increased the expression of platelet-derived growth factor (PDGF (显示 PDGFA 蛋白)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (显示 MME 蛋白)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
TGF-beta1 modulates the expression of syndecan-4 (显示 SDC4 蛋白) in cultured vascular endothelial cells in a biphasic manner.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (显示 FGF2 蛋白) expression through the activation of AP-1 (显示 JUN 蛋白) and NF-kappaB (显示 NFKB1 蛋白) in bovine mammary gland fibroblasts.
The results identify TGFB1 and ESRRA (显示 ESRRA 蛋白) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
the combined treatment with TGF-beta1 and BMP-7 (显示 BMP7 蛋白) or treatment first with TGF-beta1 followed by BMP-7 (显示 BMP7 蛋白) was more effective than other treatment groups in both chondrogenic differentiation and SZP (显示 PRG4 蛋白) secretion.
Tenascin-X (显示 TNXB 蛋白) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (显示 SMAD1 蛋白)/5/8 and Smad2 (显示 SMAD2 蛋白)/3 channels through a negative feedback loop dependent on Smad7 (显示 SMAD7 蛋白).
Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.
A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (显示 SMAD3 蛋白) signaling pathway in chronic heart failure .
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (显示 NFKB1 蛋白), and the amelioration of disc degradation.
that prenatal tracheal occlusion increases TGF-beta/Rho kinase (显示 ROCK1 蛋白) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering
Smad7 (显示 SMAD7 蛋白) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (显示 NOTCH1 蛋白) signaling target in limbal epithelial stem cells.
the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b
After NOTCH1 (显示 NOTCH1 蛋白) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (显示 Vcan 蛋白) and collagen II.
TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.
TGF beta is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 and MMP-9 (显示 MMP9 蛋白) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
TGF-beta1 regulated pAKT (显示 AKT1 蛋白) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.
SIV infection of rhesus macaques results in the emergence of IL-17 (显示 IL17A 蛋白)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (显示 IL18 蛋白) expression.
SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (显示 CD8A 蛋白)+ T cells from mesentric lymph nodes.
TGF-beta1 is activated or inactivated by MMP20 or KLK4 (显示 KLK4 蛋白) and that the amelogenin (显示 AMELX 蛋白) cleavage product is necessary for the in-solution mobility of TGF-beta1.
Activated TGF-beta signaling rescued miR (显示 MYLIP 蛋白)-143-reduced FSHR (显示 FSHR 蛋白) and intracellular signaling molecules, and miR (显示 MYLIP 蛋白)-143-induced porcine granulosa cell apoptosis.
TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (显示 PTK2 蛋白)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (显示 PTK2 蛋白) signaling is inhibited.
this study shows that TGF-beta1 protects intestinal integrity and influences Smad (显示 SMAD1 蛋白) and MAPK (显示 MAPK1 蛋白) signal pathways in intestinal epithelium cells after TNF-alpha (显示 TNF 蛋白) challenge
this study shows that anemonin may ameliorate LPS (显示 IRF6 蛋白)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (显示 EGFR 蛋白) signaling pathways
The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.
Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (显示 IL10 蛋白), and IL-6 (显示 IL6 蛋白) in ovarian follicles are reported.
Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (显示 TGFB2 蛋白) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.
TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (显示 MAPK14 蛋白) signaling, reduces CFTR (显示 CFTR 蛋白) expression to impair CFTR (显示 CFTR 蛋白)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (显示 CFTR 蛋白) mutations and ultimately would compromise male fertility.
These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.
R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (显示 SYCP3 蛋白) serves as a vegetally enriched, intrinsic factor (显示 GIF 蛋白) to ensure a prepared status of Smads for their activation.
the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.
Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.
TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (显示 SMAD4 蛋白)
sortilin (显示 SORT1 蛋白) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
Within the limitations of the study design, production of COMP (显示 COMP 蛋白) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.
Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.
Following Schistosoma exposure, TSP-1 (显示 GZMA 蛋白) levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 (显示 GZMA 蛋白) inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development.
TGF-beta/Smad (显示 SMAD1 蛋白) proteins signaling affects radiation response and prolongs survival by regulating DNA repair genes in malignant glioma.
The results indicate that EGFR (显示 EGFR 蛋白) and its activation are critical for YAP (显示 YAP1 蛋白)-mediated suppression of TGF-beta1-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1-mediated simultaneous apoptosis and epithelial mesenchymal transformation.
transforming growth factor beta (TGFbeta) signaling was upregulated in HSCs from bone marrow of mice with MLL (显示 MLL 蛋白)-AF9 (显示 MLLT3 蛋白)-induced acute myeloid leukemia (显示 BCL11A 蛋白) (AML (显示 RUNX1 蛋白)) because of excessive production of TGFbeta1, especially from megakaryocytes, and overactivation of latent TGFbeta1 protein.
TGF-beta release from platelets is necessary for podoplanin (显示 PDPN 蛋白)-mediated tumor invasion and metastasis in lung cancer.
Data suggest partial or complete transforming growth factor beta 1 (TGFBI) knockdown as a potential therapy against TGFBI-linked corneal dystrophies.
De novo formation of the biliary system by TGFbeta-mediated hepatocyte transdifferentiation
CXCL9 (显示 CXCL9 蛋白) may promote prostate cancer progression via inhibition of cytokines from T cells.
EGCG attenuated airway inflammation in asthmatic mice, decreased the percentage of Th17 cells and increased the percentage of Treg cells. The antiinflammatory effect of EGCG is achieved via the TGFbeta1 signaling pathway.
fibrosis induced by Ang II (显示 AGT 蛋白) may be alleviated by AKAP12 expression through inactivation of the TGF-beta1 pathway.
transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...
The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (显示 LDB2 蛋白).
TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (显示 SMAD5 蛋白) mediated pathway.
PCSK7 (显示 PCSK7 蛋白) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.
TGFbeta1 plays a role in zebrafish keratocyte migration.
data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (显示 SMAD4 蛋白) and preventing the formation of Smad2 (显示 SMAD2 蛋白)/3/4 and Smad1 (显示 SMAD1 蛋白)/5/9/4 complexes
TGF-beta1 acts at multiple sites, including LH receptor (显示 LHCGR 蛋白), 20beta-HSD (显示 HAL 蛋白) and membrane progestin receptor-beta (显示 PAQR8 蛋白), to inhibit zebrafish oocyte maturation
These data suggest Pez (显示 PTPN14 蛋白) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.
Data show that Rock2 (显示 ROCK2 蛋白) acts as a negative regulator of the TGFbeta signaling pathway.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
TGF-beta 1 protein
, latency-associated peptide
, transforming growth factor beta-1
, transforming growth factor, beta 1 (Camurati-Engelmann disease)
, transforming growth factor-beta 1
, transforming growth factor beta 1
, transforming growth factor-beta
, transforming growth factor beta1
, transforming growth factor-beta-1
, tgf beta
, tgf-beta 5
, transforming gorwth factor-Beta5
, transforming growth factor-B5
, transforming growth factor-beta 5
, TGF-beta 1
, regulatory protein
, transforming growth factor, beta-1
, transforming growth factor, beta 1
, transforming growth factor, beta-induced, 68kDa
, transforming growth factor beta-1-like
, transforming growth factor beta 4
, TGF beta