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PERK 抗体 (pThr980) (Alexa Fluor 647)

EIF2AK3 适用: 人, 小鼠, 大鼠, 犬, Pig WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal Alexa Fluor 647
产品编号 ABIN878623
发货至: 中国
  • 抗原 See all PERK (EIF2AK3) 抗体
    PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
    抗原表位
    • 16
    • 15
    • 11
    • 9
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr980
    适用
    人, 小鼠, 大鼠, 犬, Pig
    宿主
    • 111
    • 5
    • 3
    • 1
    克隆类型
    • 114
    • 6
    多克隆
    标记
    • 44
    • 12
    • 9
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This PERK antibody is conjugated to Alexa Fluor 647
    应用范围
    • 80
    • 58
    • 45
    • 27
    • 25
    • 25
    • 14
    • 10
    • 8
    • 6
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    犬, 人, 小鼠, Pig, 大鼠
    预测反应
    Cow,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic phosphopeptide derived from mouse PERK around the phosphorylation site of Thr980
    亚型
    IgG
    Top Product
    Discover our top product EIF2AK3 Primary Antibody
  • 应用备注
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Chen, Holstein, Aime, Bollo, Lechleiter: "Calcineurin β protects brain after injury by activating the unfolded protein response." in: Neurobiology of disease, Vol. 94, pp. 139-56, (2016) (PubMed).

  • 抗原
    PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
    别名
    PERK (EIF2AK3 产品)
    别名
    EIF2AK3 antibody, AI427929 antibody, Pek antibody, Perk antibody, PEK antibody, PERK antibody, WRS antibody, eukaryotic translation initiation factor 2 alpha kinase 3 antibody, EIF2AK3 antibody, Eif2ak3 antibody
    背景

    Synonyms: Pek, Perk, AI427929, Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, Eif2ak3

    Background: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

    基因ID
    13666
    UniProt
    Q9Z2B5
    途径
    Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response
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