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MDM2 抗体 (AA 18-22)
MDM2
适用: 人
WB
宿主: 兔
Polyclonal
unconjugated
MDM2抗体详情
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抗原
See all MDM2 抗体
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
抗原表位
All epitopes for MDM2 抗体
AA 18-22
适用
All reactivities for MDM2 抗体
人
宿主
All hosts for MDM2 抗体
兔
克隆类型
All clonalities for MDM2 抗体
多克隆
标记
All conjugates for MDM2 抗体
This MDM2 antibody is un-conjugated
应用范围
All applications for MDM2 抗体
Western Blotting (WB)
特异性
The antibody detects endogenous levels of total MDM2 protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 18-22 (Q-I-P-A-S) derived from Human MDM2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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Discover our top product MDM2 Primary Antibody
Alternatives
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使用细节
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应用备注
Western blotting: 1:500-1:1000
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
1 mg/mL
缓冲液
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C/-20 °C
储存方法
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
MDM2目标详情
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抗原
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
别名
MDM2 (MDM2 产品 )
别名
ACTFS antibody, HDMX antibody, hdm2 antibody, zgc:109834 antibody, 1700007J15Rik antibody, AA415488 antibody, Mdm-2 antibody, MDM2 proto-oncogene antibody, MDM2 proto-oncogene S homeolog antibody, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antibody, MDM2 oncogene, E3 ubiquitin protein ligase antibody, transformed mouse 3T3 cell double minute 2 antibody, MDM2 antibody, mdm2.S antibody, Mdm2 antibody, mdm2 antibody
背景
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 .
分子量
90 kDa
基因ID
4193
NCBI登录号
NP_002383
UniProt
Q00987
途径
p53 Pathway , PI3K-Akt Signaling , Cell Division Cycle , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Autophagy , Ubiquitin Proteasome Pathway
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