JMY 抗体 (AA 1-50)
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- 抗原 See all JMY 抗体
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
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抗原表位
- AA 1-50
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This JMY antibody is un-conjugated
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应用范围
- Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunoprecipitation (IP)
- 原理
- Rabbit anti-JMY Antibody, Affinity Purified
- 预测反应
- Mouse
- 纯化方法
- Affinity Purified
- 免疫原
- between AA 1 and 50
- 亚型
- IgG
- Top Product
- Discover our top product JMY Primary Antibody
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- 应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-JMY antibody A302-573A.
- 限制
- 仅限研究用
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- 浓度
- 1000 μg/mL
- 缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 有效期
- 12 months
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- 抗原
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- 别名
- JMY (JMY 产品)
- 别名
- WHDC1L3 antibody, junction mediating and regulatory protein, p53 cofactor antibody, junction-mediating and regulatory protein antibody, JMY antibody, jmy antibody, Jmy antibody
- 背景
- Background: Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) Q8N9B5].
- 基因ID
- 133746
- NCBI登录号
- NP_689618
- UniProt
- Q8N9B5
- 途径
- Regulation of Actin Filament Polymerization
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