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- 抗原 See all JMY 抗体
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
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抗原表位
- AA 2-29, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This JMY antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- M
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This JMY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human JMY.
- 克隆位点
- RB30560
- 亚型
- Ig Fraction
- Top Product
- Discover our top product JMY Primary Antibody
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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A transcription co-factor integrates cell adhesion and motility with the p53 response." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 47, pp. 19872-7, (2009) (PubMed).
: "p53-cofactor JMY is a multifunctional actin nucleation factor." in: Nature cell biology, Vol. 11, Issue 4, pp. 451-9, (2009) (PubMed).
: "Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients." in: Genes, chromosomes & cancer, Vol. 47, Issue 8, pp. 680-96, (2008) (PubMed).
: "Mdm2 targets the p53 transcription cofactor JMY for degradation." in: EMBO reports, Vol. 8, Issue 1, pp. 84-90, (2007) (PubMed).
: "A novel cofactor for p300 that regulates the p53 response." in: Molecular cell, Vol. 4, Issue 3, pp. 365-76, (1999) (PubMed).
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A transcription co-factor integrates cell adhesion and motility with the p53 response." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 47, pp. 19872-7, (2009) (PubMed).
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- 抗原
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- 别名
- JMY (JMY 产品)
- 别名
- WHDC1L3 antibody, junction mediating and regulatory protein, p53 cofactor antibody, junction-mediating and regulatory protein antibody, JMY antibody, jmy antibody, Jmy antibody
- 背景
- JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
- 分子量
- 111445
- NCBI登录号
- NP_689618
- UniProt
- Q8N9B5
- 途径
- Regulation of Actin Filament Polymerization
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