ARH12 antibody, ARHA antibody, RHO12 antibody, RHOH12 antibody, Arha antibody, Arha1 antibody, Arha2 antibody, arha antibody, arha2 antibody, xrhoa antibody, arh12 antibody, rho12 antibody, rhoh12 antibody, rhoa antibody, RHO1 antibody, Rhoa antibody, wu:fa66g04 antibody, wu:fb26g07 antibody, zgc:66058 antibody, zgc:85805 antibody, ARHC antibody, rhoae antibody, zgc:64015 antibody, ras homolog family member A antibody, ras homolog family member A S homeolog antibody, ras homolog family member A L homeolog antibody, ras homolog gene family, member Aa antibody, ras homolog family member Ca antibody, RHOA antibody, Rhoa antibody, rhoa.S antibody, rhoa antibody, rhoa.L antibody, rhoaa antibody, rhoca antibody
背景
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.