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TNFRSF10B 抗体 (AA 266-393)

This 小鼠 单克隆 antibody specifically detects TNFRSF10B in IHC 和 StM. It exhibits reactivity toward 人.
产品编号 ABIN6940975
发货至: 中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Quick Overview for TNFRSF10B 抗体 (AA 266-393) (ABIN6940975)

抗原

See all TNFRSF10B 抗体
TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

适用

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宿主

  • 91
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小鼠

克隆类型

  • 91
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  • 2
单克隆

标记

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This TNFRSF10B antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Staining Methods (StM)

克隆位点

DR5-3381
  • 抗原表位

    • 15
    • 11
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    AA 266-393

    纯化方法

    Purified by Protein A/G

    免疫原

    Recombinant human DR5 protein fragment (around aa266-393) (exact sequence is proprietary)

    亚型

    IgG1 kappa
  • 应用备注

    Positive Control: Human colon cancer or endometrial tissue (IHC).

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

    别名

    TNFRSF10B

    背景

    Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes Fas antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the death domain , that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including Fas, DR2 (or TRUNDD), DR3 (death receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.

    分子量

    48kDa

    基因ID

    8795, 521456

    途径

    p53 Pathway, Apoptosis, Positive Regulation of Endopeptidase Activity
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