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TCF7L2 抗体 (AA 401-550)

TCF7L2 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN674349
发货至: 中国
  • 抗原 See all TCF7L2 抗体
    TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
    抗原表位
    • 14
    • 11
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-550
    适用
    • 41
    • 30
    • 29
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    大鼠
    宿主
    • 53
    • 7
    克隆类型
    • 44
    • 16
    多克隆
    标记
    • 29
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TCF7L2 antibody is un-conjugated
    应用范围
    • 39
    • 24
    • 13
    • 12
    • 10
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    大鼠
    预测反应
    Human,Mouse,Dog,Cow,Pig,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human TCF7L2
    亚型
    IgG
    Top Product
    Discover our top product TCF7L2 Primary Antibody
  • 应用备注
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
    别名
    TCF7L2 (TCF7L2 产品)
    别名
    TCF4B antibody, TCF4E antibody, Tcf-4 antibody, Tcf4 antibody, mTcf-4B antibody, mTcf-4E antibody, tcf4 antibody, XTCF-4 antibody, tcf4e antibody, TCF4 antibody, TCF-4 antibody, TCFL2 antibody, transcription factor 7 like 2 antibody, transcription factor 7-like 2 antibody, transcription factor 7 like 2, T cell specific, HMG box antibody, transcription factor 7 like 2 L homeolog antibody, transcription factor 7-like 2 (T-cell specific, HMG-box) antibody, TCF7L2 antibody, LOC100545943 antibody, Tcf7l2 antibody, tcf7l2 antibody, tcf7l2.L antibody
    背景

    Synonyms: TCF4, TCF-4, Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, hTCF-4, TCF7L2

    Background: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

    基因ID
    6934
    UniProt
    Q9NQB0
    途径
    WNT signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus
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