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PTPN11 抗体 (AA 526-551)

Name: PTPN11 抗体 (AA 526-551)
SKU: ABIN6243732
Availability: OutOfStock

PTPN11 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21493 unconjugated

Western blot analysis of SHP2 Antibody (ABIN6243732 and ABIN6579046) in 293, K562 cell line lysates (35 μg/lane). (PTPN11 抗体 (AA 526-551))

Flow cytometric analysis of 293 cells using SHP2 Antibody (bottom histogram) compared to a negative control cell (top histogram). (PTPN11 抗体 (AA 526-551))

FACS

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SHP2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (PTPN11 抗体 (AA 526-551))

IHC (p)

3 images

(1 reference)

产品编号 ABIN6243732

发货至: 中国

Datasheet as PDF

抗原 See all PTPN11 抗体

PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
抗原表位
32

25

15

15

9

7

7

6

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 526-551
适用
153

116

105

10

10

9

8

8

8

7

5

5

4

3

1
人
宿主
168

14

2

1
兔
Compatible Secondaries
克隆类型
148

37
多克隆
标记
87

12

9

9

9

9

9

9

7

5

3

3

2

2

2

2

2

2

2
This PTPN11 antibody is un-conjugated
应用范围
120

50

42

27

26

25

20

15

14

7

6

3

2

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

预测反应

C, M, Rat

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This SHP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 526-551 amino acids from human SHP2.

克隆位点

RB21493

亚型

Ig Fraction

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anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) antibody
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anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (C-Term) antibody
KO Validated PTPN11 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) antibody
PTPN11 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-460) antibody
PTPN11 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated

anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (C-Term) antibody
PTPN11 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (pTyr580) antibody
PTPN11 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (pTyr542) antibody
PTPN11 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Chang, Gao, Han, Du, Liu, Wang, Tan, Zhang, Liu, Zhu, Yu, Fan, Zhang, Zhou, Wang, Fu, Cao: "Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma." in: Gut, Vol. 63, Issue 9, pp. 1457-67, (2014) (PubMed).
抗原

PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

别名

SHP2 (PTPN11 产品)

别名

BPTP3 antibody, CFC antibody, NS1 antibody, PTP-1D antibody, PTP2C antibody, SH-PTP2 antibody, SH-PTP3 antibody, SHP2 antibody, 2700084A17Rik antibody, AW536184 antibody, PTP1D antibody, SAP-2 antibody, SHP-2 antibody, Shp2 antibody, Syp antibody, SYP antibody, bptp3 antibody, cfc antibody, ns1 antibody, ptp-2 antibody, ptp2c antibody, ptpn11 antibody, ptpn11-a antibody, ptpn11-b antibody, shp-2 antibody, shp2 antibody, fa14b09 antibody, wu:fa14b09 antibody, wu:fi24f03 antibody, zgc:55388 antibody, zgc:63553 antibody, protein tyrosine phosphatase, non-receptor type 11 antibody, protein tyrosine phosphatase, non-receptor type 11 S homeolog antibody, protein tyrosine phosphatase, non-receptor type 11, a antibody, protein tyrosine phosphatase, non-receptor type 11, b antibody, PTPN11 antibody, Ptpn11 antibody, ptpn11.S antibody, ptpn11a antibody, ptpn11b antibody

物质类

Viral Protein

背景

SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

分子量

68011

NCBI登录号

NP_002825, NP_542168

UniProt

Q06124

途径

JAK/STAT Signaling, RTK signaling, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effect