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JMY 抗体

JMY 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5704810
发货至: 中国
  • 抗原 See all JMY 抗体
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    适用
    • 45
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 42
    • 4
    克隆类型
    • 42
    • 3
    多克隆
    标记
    • 25
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This JMY antibody is un-conjugated
    应用范围
    • 31
    • 28
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    免疫原
    junction mediating and regulatory protein, p53 cofactor
    亚型
    IgG
    Top Product
    Discover our top product JMY Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04443( JMY Antibody) at dilution of 1:1000

    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze / thaw cycles.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    别名
    JMY (JMY 产品)
    别名
    WHDC1L3 antibody, junction mediating and regulatory protein, p53 cofactor antibody, junction-mediating and regulatory protein antibody, JMY antibody, jmy antibody, Jmy antibody
    背景
    Synonyms:JMY, WHDC1L3 Background:Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location(By similarity).
    分子量
    111 kDa
    基因ID
    133746
    UniProt
    Q8N9B5
    途径
    Regulation of Actin Filament Polymerization
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