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TNFRSF10B 抗体 (AA 233-440)

This anti-TNFRSF10B antibody is a 兔 多克隆 antibody detecting TNFRSF10B in WB, FACS 和 IHC. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 1 publication.
Pubmed (1 reference)
产品编号 ABIN5518794
发货至: 中国

Quick Overview for TNFRSF10B 抗体 (AA 233-440) (ABIN5518794)

抗原

See all TNFRSF10B 抗体
TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

适用

  • 118
  • 23
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  • 1
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人, 小鼠, 大鼠

宿主

  • 84
  • 47
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兔

克隆类型

  • 76
  • 58
  • 2
多克隆

标记

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This TNFRSF10B antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
Discover our top product TNFRSF10B Primary Antibody

  • 抗原表位

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    AA 233-440

    原理

    Anti-DR5/TNFRSF10B Antibody Picoband®

    交叉反应 （详细）

    No cross-reactivity with other proteins

    产品特性

    Anti-DR5/TNFRSF10B Antibody Picoband® (ABIN5518794). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human DR5 recombinant protein (Position: K233-S440). Human DR5 shares 48.4% amino acid (aa) sequence identity with mouse DR5.

    亚型

    IgG
  • anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 234-435) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 234-435) antibody

    TNFRSF10B 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibody

    TNFRSF10B 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 1-440) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 1-440) antibody

    TNFRSF10B 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 71-170) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 71-170) antibody

    TNFRSF10B 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2D6 unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 266-393) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 266-393) antibody

    TNFRSF10B 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal DR5-3381 unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (N-Term) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (N-Term) antibody

    TNFRSF10B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-210) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-210) antibody

    TNFRSF10B 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2H5B8 unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 301-381) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 301-381) antibody

    TNFRSF10B 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibody

    TNFRSF10B 适用: 人, 小鼠 WB, ICC 宿主: 小鼠 Monoclonal unconjugated

    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-186) antibody
    anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-186) antibody

    TNFRSF10B 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM113 unconjugated

  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Finnberg, N., Klein-Szanto, A. J. P., El-Deiry, W. S.TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.J. Clin. Invest. 118: 111-123, 2008. 2. Takeda, K., Kojima, Y., Ikejima, K., Harada, K., Yamashina, S., Okumura, K., Aoyama, T., Frese, S., Ikeda, H., Haynes, N. M., Cretney, E., Yagita, H., Sueyoshi, N., Sato, N., Nakanuma, Y., Smyth, M. J., Okumura, K.Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.Proc. Nat. Acad. Sci. 105: 10895-10900, 2008. 3. Walczak, H., Degli-Esposti, M. A., Johnson, R. S., Smolak, P. J., Waugh, J. Y., Boiani, N., Timour, M. S., Gerhart, M. J., Schooley, K. A., Smith, C. A., Goodwin, R. G., Rauch, C. T.TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.EMBO J. 16: 5386-5397, 1997.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用

  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Liu, Zuo, Wang, Chen, Yang, Wang, Zhu: "miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT." in: Oncotarget, Vol. 5, Issue 13, pp. 4959-71, (2014) (PubMed).

  • 抗原

    TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

    别名

    TNFRSF10B

    背景

    Synonyms: Tumor necrosis factor receptor superfamily member 10B,Death receptor 5,TNF-related apoptosis-inducing ligand receptor 2,TRAIL receptor 2,TRAIL-R2,CD262,TNFRSF10B,DR5, KILLER, TRAILR2, TRICK2, ZTNFR9,UNQ160/PRO186,

    Tissue Specificity: Widely expressed in adult and fetal tissues, very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361, highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract, not detectable in brain.

    Background: TNFRSF10B (Tumor necrosis factor receptor superfamily, member 10b) is a human gene. It is also known as DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.By analysis of radiation hybrid panels, this gene is mapped to chromosome 8p22-p21. Northern blot analysis indicated that TRAILR2 was expressed as a 4.4-kb mRNA in all tissues tested, with the highest levels of expression in peripheral blood lymphocytes, spleen, and ovary.

    分子量

    60 kDa

    基因ID

    8795

    UniProt

    O14763

    途径

    p53 Pathway, Apoptosis, Positive Regulation of Endopeptidase Activity
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