WWTR1 抗体 (C-Term)
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- 抗原 See all WWTR1 抗体
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This WWTR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- PPTMTPDMRS ITNNSSDPFL NGGPYHSREQ STDSGLGLGC YSVPTTPEDF
- 产品特性
- This is a rabbit polyclonal antibody against WWTR1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human WWTR1
- Top Product
- Discover our top product WWTR1 Primary Antibody
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anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 1-230) antibody
WWTR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (N-Term) antibodyWWTR1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 201-300) antibodyWWTR1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1F1 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal CL0371 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人, 小鼠, 大鼠 WB, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (C-Term) antibodyWWTR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 296-330), (C-Term) antibodyWWTR1 适用: 人 WB 宿主: 兔 Polyclonal RB51589 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 296-330), (C-Term) antibodyWWTR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51590 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
- 别名
- WWTR1 (WWTR1 产品)
- 别名
- WWTR1 antibody, TAZ antibody, 2310058J06Rik antibody, 2610021I22Rik antibody, C78399 antibody, Taz antibody, WW domain containing transcription regulator 1 L homeolog antibody, WW domain containing transcription regulator 1 antibody, wwtr1.L antibody, wwtr1 antibody, WWTR1 antibody, Wwtr1 antibody
- 背景
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WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. It regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. And it regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Alias Symbols: WWTR1, TAZ,
Protein Interaction Partner: MED28, NOTCH1, YWHAQ, LATS1, BTRC, YWHAE, TP53BP2, PPP1CA, KLF5, YWHAZ, YWHAG, PAX3, SLC9A3R2, TEAD3, TEAD4, NKX2-1, RUNX1,
Protein Size: 400 - 基因ID
- 25937
- NCBI登录号
- NP_056287
- UniProt
- Q9GZV5
- 途径
- Regulation of Lipid Metabolism by PPARalpha
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