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WWTR1 抗体 (C-Term)

WWTR1 适用: 人 WB 宿主: 兔 Polyclonal RB51589 unconjugated
产品编号 ABIN6243336
发货至: 中国
  • 抗原 See all WWTR1 抗体
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    抗原表位
    • 10
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 296-330, C-Term
    适用
    • 37
    • 16
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 33
    • 4
    克隆类型
    • 33
    • 4
    多克隆
    标记
    • 22
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This WWTR1 antibody is un-conjugated
    应用范围
    • 30
    • 16
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This WWTR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 296-330 amino acids from the C-terminal region of human WWTR1.
    克隆位点
    RB51589
    亚型
    Ig Fraction
    Top Product
    Discover our top product WWTR1 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    别名
    WWTR1 (WWTR1 产品)
    别名
    WWTR1 antibody, TAZ antibody, 2310058J06Rik antibody, 2610021I22Rik antibody, C78399 antibody, Taz antibody, WW domain containing transcription regulator 1 L homeolog antibody, WW domain containing transcription regulator 1 antibody, wwtr1.L antibody, wwtr1 antibody, WWTR1 antibody, Wwtr1 antibody
    背景
    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
    分子量
    44101
    UniProt
    Q9GZV5
    途径
    Regulation of Lipid Metabolism by PPARalpha
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