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WWTR1 抗体 (AA 1-230)

WWTR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6150278
发货至: 中国
  • 抗原 See all WWTR1 抗体
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    抗原表位
    • 11
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 1-230
    适用
    • 37
    • 16
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 33
    • 4
    克隆类型
    • 33
    • 4
    多克隆
    标记
    • 22
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This WWTR1 antibody is un-conjugated
    应用范围
    • 30
    • 16
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    序列
    MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human TAZ (NP_056287.1).
    亚型
    IgG
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    说明

    HIGH QUALITY

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    别名
    WWTR1 (WWTR1 产品)
    别名
    WWTR1 antibody, TAZ antibody, 2310058J06Rik antibody, 2610021I22Rik antibody, C78399 antibody, Taz antibody, WW domain containing transcription regulator 1 L homeolog antibody, WW domain containing transcription regulator 1 antibody, wwtr1.L antibody, wwtr1 antibody, WWTR1 antibody, Wwtr1 antibody
    背景
    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.,WW domain-containing transcription regulator protein 1,Transcriptional coactivator with PDZ-binding motif,TAZ,WWTR1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,WWTR1
    分子量
    44 kDa
    基因ID
    25937
    UniProt
    Q9GZV5
    途径
    Regulation of Lipid Metabolism by PPARalpha
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