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WWTR1 产品

(WW Domain Containing Transcription Regulator 1 (WWTR1))

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This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010].

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Featured WWTR1 Categories

WWTR1 抗体

High quality antibodies with extensive validation data.

WWTR1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended WWTR1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN6150278
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Application WB
Validations
  • (5)
Cat. No. ABIN2779708
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (3)
Cat. No. ABIN525503
Quantity 100 μg
Datasheet Datasheet

Recommended WWTR1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325410
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325412
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3096356
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our WWTR1 Products

Hwang, Kim, Kim, Il Park, Oh, Moon, Byun, Jeong, Kim, Yaffe, Hwang, Hong: "TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression." in: Nature communications, Vol. 10, Issue 1, pp. 421, (2019) (PubMed).

Wu, Deng, Wang, Zhao, Wang, Rao, Xu, Zhou, Choi, Rizvi, Remke, Rubin, Johnson, Carroll, Stemmer-Rachamimov, Wu, Zheng, Xin, Ratner, Lu: "Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis." in: Cancer cell, Vol. 33, Issue 2, pp. 292-308.e7, (2018) (PubMed).

Yu, Huo, Liu, Deng, Szymanski, Li, Luo, Hong, Lin, Wang: "PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ." in: Cell stem cell, Vol. 23, Issue 2, pp. 193-209.e5, (2018) (PubMed).

Xiang, Wang, Zhang, Piao, Muthusamy, Wang, Deng, Zhang, Kuang, Billadeau, Huang, Lai, Urrutia, Kang: "Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway." in: NPJ precision oncology, Vol. 2, Issue 1, pp. 2, (2018) (PubMed).

Sero, Bakal: "Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion." in: Cell systems, Vol. 4, Issue 1, pp. 84-96.e6, (2017) (PubMed).

Deng, Wu, Bai, Zhao, Wang, Wang, Xu, Sakabe, Zhou, Xin, Lu: "A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination." in: Nature communications, Vol. 8, pp. 15161, (2017) (PubMed).

Zhang, Wang, Ding, Damaolar, Li, Qiu, Yin: "Lentivirus-TAZ Administration Alleviates Osteoporotic Phenotypes in the Femoral Neck of Ovariectomized Rats." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 38, Issue 1, pp. 283-94, (2016) (PubMed).

Slemmons, Crose, Rudzinski, Bentley, Linardic: "Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma." in: PLoS ONE, Vol. 10, Issue 10, pp. e0140781, (2015) (PubMed).

Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).

Xiang, Gilkes, Hu, Luo, Bullen, Liang, Semenza: "HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells." in: Oncotarget, Vol. 6, Issue 14, pp. 11768-78, (2015) (PubMed).

Synonyms and alternative names related to WWTR1

WW domain containing transcription regulator 1 L homeolog (wwtr1.L), WW domain containing transcription regulator 1 (wwtr1), WW domain containing transcription regulator 1 (WWTR1), WW domain containing transcription regulator 1 (Wwtr1), 2310058J06Rik, 2610021I22Rik, C78399, TAZ, Taz, WWTR1

Protein level used designations for WWTR1

  • WW domain containing transcription regulator 1
  • WW domain-containing transcription regulator protein 1
  • taz
  • WW domain-containing transcription regulator protein 1-like
  • transcriptional co-activator with PDZ-binding motif
  • transcriptional coactivator with PDZ-binding motif
  • transcriptional coactivator with PDZ binding motif
  • transcriptional co-activator with PDZ-binding motif (TA)Z
  • transcriptional co-activator with PDZ-binding motif (TAZ)
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