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WWOX 产品

(WW Domain Containing Oxidoreductase (WWOX))

Categories

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008].

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Featured WWOX Categories

WWOX 抗体

High quality antibodies with extensive validation data.

WWOX ELISA试剂盒

Reliable ELISA kits for a wide range of species.

WWOX 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended WWOX 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, IP
Validations
  • (6)
Cat. No. ABIN7175871
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (3)
Cat. No. ABIN670551
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (5)
Cat. No. ABIN5693294
Quantity 100 μg
Datasheet Datasheet

Recommended WWOX ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380821
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1167525
Quantity 96 tests
Datasheet Datasheet

Recommended WWOX 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1325403
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096408
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7278826
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our WWOX Products

Henssen, Koche, Zhuang, Jiang, Reed, Eisenberg, Still, MacArthur, Rodríguez-Fos, Gonzalez, Puiggròs, Blackford, Mason, de Stanchina, Gönen, Emde, Shah, Arora, Reeves, Socci, Perlman, Antonescu et al.: "PGBD5 promotes site-specific oncogenic mutations in human tumors. ..." in: Nature genetics, Vol. 49, Issue 7, pp. 1005-1014, (2017) (PubMed).

Zhang, Zhang, Cong, Zhang: "The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients." in: Diagnostic pathology, Vol. 7, pp. 181, (2013) (PubMed).

Fabbri, Iliopoulos, Trapasso, Aqeilan, Cimmino, Zanesi, Yendamuri, Han, Amadori, Huebner, Croce: "WWOX gene restoration prevents lung cancer growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 43, pp. 15611-6, (2005) (PubMed).

Park, Ludes-Meyers, Zimonjic, Durkin, Popescu, Aldaz: "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma." in: British journal of cancer, Vol. 91, Issue 4, pp. 753-9, (2004) (PubMed).

Chang, Doherty, Ensign: "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9195-202, (2003) (PubMed).

Bednarek, Keck-Waggoner, Daniel, Laflin, Bergsagel, Kiguchi, Brenner, Aldaz: "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth." in: Cancer research, Vol. 61, Issue 22, pp. 8068-73, (2001) (PubMed).

Paige, Taylor, Taylor, Hillier, Farrington, Scott, Porteous, Smyth, Gabra, Watson: "WWOX: a candidate tumor suppressor gene involved in multiple tumor types." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11417-22, (2001) (PubMed).

Bednarek, Laflin, Daniel, Liao, Hawkins, Aldaz: "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer." in: Cancer research, Vol. 60, Issue 8, pp. 2140-5, (2000) (PubMed).

Ried, Finnis, Hobson, Mangelsdorf, Dayan, Nancarrow, Woollatt, Kremmidiotis, Gardner, Venter, Baker, Richards: "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells." in: Human molecular genetics, Vol. 9, Issue 11, pp. 1651-63, (2000) (PubMed).

Synonyms and alternative names related to WWOX

WW domain containing oxidoreductase (Wwox), WW domain-containing oxidoreductase (LOC411815), WW domain containing oxidoreductase (WWOX), WW domain-containing oxidoreductase (CpipJ_CPIJ004939), WW domain-containing oxidoreductase (MCYG_01584), WW domain-containing oxidoreductase (VDBG_05631), WW domain-containing oxidoreductase (VDBG_01326), WW domain-containing oxidoreductase (VDBG_06753), WW domain-containing oxidoreductase (Tsp_03967), WW domain-containing oxidoreductase (LOC100284583), WW domain containing oxidoreductase (wwox), WW domain-containing oxidoreductase (Wwox), 5330426P09Rik, 9030416C10Rik, anon-EST:Posey177, CG7221, D16S432E, Dmel\\CG7221, DmWWOX, FOR, FRA16D, GB11795, HHCMA56, PRO0128, SDR41C1, WOX1, WWOX, zgc:55975

Protein level used designations for WWOX

  • CG7221-PA
  • Wwox-PA
  • WW domain-containing oxidoreductase
  • retinol dehydrogenase 12
  • WW domain containing oxidoreductase
  • WW domain-containing protein WWOX
  • fragile site FRA16D oxidoreductase
  • short chain dehydrogenase/reductase family 41C, member 1
  • WW-domain oxidoreductase
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