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eIF4EBP1 抗体
EIF4EBP1
适用: 人, 小鼠, 大鼠
IHC (p)
宿主: 兔
Polyclonal
unconjugated
eIF4EBP1抗体详情
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抗原
See all eIF4EBP1 (EIF4EBP1) 抗体
eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
适用
All reactivities for eIF4EBP1 抗体
人, 小鼠, 大鼠
宿主
All hosts for eIF4EBP1 抗体
兔
克隆类型
All clonalities for eIF4EBP1 抗体
多克隆
标记
All conjugates for eIF4EBP1 抗体
This eIF4EBP1 antibody is un-conjugated
应用范围
All applications for eIF4EBP1 抗体
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
特异性
This antibody detects endogenous levels of 4E-BP1 protein. (region surrounding Arg51)
交叉反应 (详细)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
纯化方法
Affinity chromatography
纯度
> 95 % by SDS-PAGE
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使用细节
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应用备注
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
贮存及处理
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浓度
1,0 mg/mL
缓冲液
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
eIF4EBP1目标详情
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抗原
eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
别名
EIF4EBP1 / 4E-BP1 (EIF4EBP1 产品 )
别名
4E-BP1 antibody, 4EBP1 antibody, BP-1 antibody, PHAS-I antibody, 4e-bp1 antibody, AA959816 antibody, 153432_at antibody, 43-BP antibody, 4E-BP antibody, 4EBP antibody, 4e-bp antibody, 4eBP antibody, 4ebp antibody, BcDNA.HL08053 antibody, BcDNA:HL08053 antibody, CG8846 antibody, CT8705 antibody, Dm 4E-BP antibody, Dmel\\CG8846 antibody, Phas1 antibody, Thor/EIF4EBP antibody, anon-WO0172774.158 antibody, d4E-BP antibody, d4E-BP1 antibody, d4EBP antibody, d4e-bp antibody, d4eBP antibody, dthor antibody, eIF4E-BP antibody, l(2)06270 antibody, l(2)k07736 antibody, l(2)k13517 antibody, pp20 antibody, thor antibody, EIF4EBP1 antibody, fc04h09 antibody, wu:fc04h09 antibody, zgc:64137 antibody, eukaryotic translation initiation factor 4E binding protein 1 antibody, CG8846 gene product from transcript CG8846-RA antibody, EIF4EBP1 antibody, Eif4ebp1 antibody, Thor antibody, eif4ebp1 antibody
背景
The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.Synonyms: Eukaryotic translation initiation factor 4E-binding protein 1, PHAS-1, PHAS-I, PHAS1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, eIF4E-binding protein 1
分子量
approx. 15 to 20 kDa
基因ID
1978
NCBI登录号
NP_004086
UniProt
Q13541
途径
MAPK Pathway , PI3K-Akt Signaling , RTK signaling , AMPK Signaling , Regulation of Cell Size , BCR Signaling
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