This antibody detects endogenous levels of Tsc2 protein. (region surrounding Pro945)
交叉反应 (详细)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
纯化方法
Affinity chromatography
纯度
> 95 % by SDS-PAGE
免疫原
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S1254 of human TSC2.
TSC2 is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Mutations in TSC2 lead to tuberous sclerosis complex.Synonyms: TSC4, Tuberous sclerosis 2 protein